The present study aims to identify promising oil and gas bearing objects in the eastern part of the Gulf of Suez. Three-dimensional (3D) modelling of the study area using Petrel software was carried out. The basement layer was created using airborne magnetic data through 3D modelling using GM-SYS-3D software. The sedimentary succession was generated using interpreted seismic sections and well data, and then the data was localised and digitised using Petrel software to be used in the building of the model. The lithology and age of each layer were accurately determined to be used in building the petroleum system model. Data about the temperature gradient and thermal conductivity were obtained for different wells along the Gulf of Suez and the eastern shoulder of the Gulf. In addition to that, heat flow values of the study area have been computed and the heat flow map was created to be used in predicting oil and gas accumulation in the study area. Information about hydrocarbon masses and volumes generated and expelled from the source rocks as well as the amount that has migrated and accumulated in reservoirs were computed through running forward simulation using PetroMod software. Accumulations of oil and gas are modelled in the different reservoir layers in the study area. New accumulations of oil and gas were generated within the study area; these accumulations have not been discovered yet. The study area needs more detailed 2D and 3D investigation in the predicted promising locations, where the probability of the existence of hydrocarbon is high. In the southeastern part of the area no activity has been done and according to the results of the petroleum system model, hydrocarbon accumulation area could be discovered in this area in different reservoirs.