TY - JOUR

T1 - PET Radiochemistry Automation: State of the Art and Future Trends in F-18-nucleophilic Fluorination

AU - Krasikova, Raisa

PY - 2013

Y1 - 2013

N2 - This review article summarizes the recent information regarding general aspects in the automated synthesis of F-18-labelled PET radiotracers that are prepared via nucleophilic fluorination pathway. The previous and on-going researches in development of different automation solutions are discussed and the current trends in large scale production of radiotracers are considered. The advantages and limitations of the fully automated systems available from different manufacturers are exemplified by routine automated production of several clinically relevant F-18-radiotracers using traditional automated synthesizers, kit-based (cassette-type) radiochemistry modules and modular systems.

AB - This review article summarizes the recent information regarding general aspects in the automated synthesis of F-18-labelled PET radiotracers that are prepared via nucleophilic fluorination pathway. The previous and on-going researches in development of different automation solutions are discussed and the current trends in large scale production of radiotracers are considered. The advantages and limitations of the fully automated systems available from different manufacturers are exemplified by routine automated production of several clinically relevant F-18-radiotracers using traditional automated synthesizers, kit-based (cassette-type) radiochemistry modules and modular systems.

M3 - Article

VL - 17

JO - Current Organic Chemistry

JF - Current Organic Chemistry

SN - 1385-2728

IS - 19

ER -