Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Peripheral blood lymphocyte changes after stereotactic ablative body radiotherapy to lung or liver metastases in patients with oligometastatic cancers. / Novikov, Sergey Nikolaevich; Baldueva, Irina Aleksandrovna; Zozulya, Anton Yurievich; Emelyanova, Natalya Viktorovna; Girdyuk, Dmitriy Viktorovich; Arsenyev, Andrey Ivanovich; Alexandrovna, Elena; Tyuryaeva, Elena Ivanovna; Antipov, E I Filip Evgenevich; Girshovich, Mikhail Markovich; Kanayev, Sergey Vasilevich.
в: Radiation Oncology Journal, Том 41, № 1, 31.03.2023, стр. 23-31.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Peripheral blood lymphocyte changes after stereotactic ablative body radiotherapy to lung or liver metastases in patients with oligometastatic cancers
AU - Novikov, Sergey Nikolaevich
AU - Baldueva, Irina Aleksandrovna
AU - Zozulya, Anton Yurievich
AU - Emelyanova, Natalya Viktorovna
AU - Girdyuk, Dmitriy Viktorovich
AU - Arsenyev, Andrey Ivanovich
AU - Alexandrovna, Elena
AU - Tyuryaeva, Elena Ivanovna
AU - Antipov, E I Filip Evgenevich
AU - Girshovich, Mikhail Markovich
AU - Kanayev, Sergey Vasilevich
PY - 2023/3/31
Y1 - 2023/3/31
N2 - PURPOSE: To perform the analysis of the peripheral blood lymphocyte changes after stereotactic ablative radiotherapy (SABR) in patients with oligometastatic cancers.MATERIALS AND METHODS: The dynamics of the immune status in peripheral blood was prospectively evaluated in 46 patients with lung (17 cases) or liver (29 cases) metastases treated by SABR. Flow cytometry of peripheral blood lymphocyte subpopulations was performed before SABR, 3-4 weeks and 6-8 weeks after the end of SABR: 3 fractions of 15-20 Gy or 4 fractions of 13.5 Gy. The number of treated lesions varied from 1 (32 patients) to 2-3 (14 patients).RESULTS: SABR induced a significant increase of T-lymphocytes (CD3+CD19-) (p = 0.001), T-helper (CD3+CD4+) (p = 0.004), activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+) (p = 0.001), activated T-helpers (CD3+CD4+HLA-DR+) (p < 0.001). A significant decrease of T-regulated immune suppressive lymphocytes (CD4+CD25brightCD127low) (p = 0.002) and NKT-cells (CD3+CD16+CD56+) (p = 0.007) was recorded after the SABR. The comparative analysis demonstrated that lower doses of SABR (EQD2Gy(α/β=10) = 93.7-105.7 Gy) induced significant increase of T-lymphocytes, activated cytotoxic T-lymphocytes, and activated CD4+CD25+ T-helpers, while SABR with higher doses (EQD2Gy(α/β=10) = 150 Gy) was not associated with these effects. A more efficient activations of T-lymphocytes (p = 0.010), activated T-helpers (p < 0.001), and cytotoxic T-lymphocytes (p = 0.003) were associated with SABR to a single lesion. A significant increase of T-lymphocytes (p = 0.002), T-helpers (p = 0.003), and activated cytotoxic T-lymphocytes (p = 0.001) was observed after SABR for hepatic metastases in contrast to SABR for lung lesions.CONCLUSION: Changes in peripheral blood lymphocytes after SABR could be influenced by the location or the number of irradiated metastasis, and the dose of SABR.
AB - PURPOSE: To perform the analysis of the peripheral blood lymphocyte changes after stereotactic ablative radiotherapy (SABR) in patients with oligometastatic cancers.MATERIALS AND METHODS: The dynamics of the immune status in peripheral blood was prospectively evaluated in 46 patients with lung (17 cases) or liver (29 cases) metastases treated by SABR. Flow cytometry of peripheral blood lymphocyte subpopulations was performed before SABR, 3-4 weeks and 6-8 weeks after the end of SABR: 3 fractions of 15-20 Gy or 4 fractions of 13.5 Gy. The number of treated lesions varied from 1 (32 patients) to 2-3 (14 patients).RESULTS: SABR induced a significant increase of T-lymphocytes (CD3+CD19-) (p = 0.001), T-helper (CD3+CD4+) (p = 0.004), activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+) (p = 0.001), activated T-helpers (CD3+CD4+HLA-DR+) (p < 0.001). A significant decrease of T-regulated immune suppressive lymphocytes (CD4+CD25brightCD127low) (p = 0.002) and NKT-cells (CD3+CD16+CD56+) (p = 0.007) was recorded after the SABR. The comparative analysis demonstrated that lower doses of SABR (EQD2Gy(α/β=10) = 93.7-105.7 Gy) induced significant increase of T-lymphocytes, activated cytotoxic T-lymphocytes, and activated CD4+CD25+ T-helpers, while SABR with higher doses (EQD2Gy(α/β=10) = 150 Gy) was not associated with these effects. A more efficient activations of T-lymphocytes (p = 0.010), activated T-helpers (p < 0.001), and cytotoxic T-lymphocytes (p = 0.003) were associated with SABR to a single lesion. A significant increase of T-lymphocytes (p = 0.002), T-helpers (p = 0.003), and activated cytotoxic T-lymphocytes (p = 0.001) was observed after SABR for hepatic metastases in contrast to SABR for lung lesions.CONCLUSION: Changes in peripheral blood lymphocytes after SABR could be influenced by the location or the number of irradiated metastasis, and the dose of SABR.
KW - Abscopal effect
KW - Dose fractionation
KW - Immune response
KW - Stereotactic body radiotherapy
UR - https://www.mendeley.com/catalogue/23cb7d6d-4609-3cef-a35d-28cc1b952fdb/
U2 - 10.3857/roj.2022.00521
DO - 10.3857/roj.2022.00521
M3 - Article
C2 - 37013415
VL - 41
SP - 23
EP - 31
JO - Radiation Oncology Journal
JF - Radiation Oncology Journal
SN - 2234-1900
IS - 1
ER -
ID: 115245389