Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Pangolin genomes and the evolution of mammalian scales and immunity. / Choo, Slew Woh; Rayko, Mike; Tan, Tze King; Hari, Ranjeev; Komissarov, Aleksey; Wee, Wei Yee; Yurchenko, Andrey A.; Kliver, Sergey; Tamazian, Gaik; Antunes, Agostinho; Wilson, Richard K.; Warren, Wesley C.; Koepfli, Klaus-Peter; Minx, Patrick; Krasheninnikova, Ksenia; Kotze, Antoinette; Dalton, Desire L.; Vermaak, Elaine; Paterson, Ian C.; Dobrynin, Pavel; Sitam, Frankie Thomas; Rovie-Ryan, Jeffrine J.; Johnson, Warren E.; Yusoff, Aini Mohamed; Luo, Shu-Jin; Karuppannan, Kayal Vizi; Fang, Gang; Zheng, Deyou; Gerstein, Mark B.; Lipovich, Leonard; O'Brien, Stephen J.; Wong, Guat Jah.
в: Genome Research, Том 26, № 10, 2016.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Pangolin genomes and the evolution of mammalian scales and immunity
AU - Choo, Slew Woh
AU - Rayko, Mike
AU - Tan, Tze King
AU - Hari, Ranjeev
AU - Komissarov, Aleksey
AU - Wee, Wei Yee
AU - Yurchenko, Andrey A.
AU - Kliver, Sergey
AU - Tamazian, Gaik
AU - Antunes, Agostinho
AU - Wilson, Richard K.
AU - Warren, Wesley C.
AU - Koepfli, Klaus-Peter
AU - Minx, Patrick
AU - Krasheninnikova, Ksenia
AU - Kotze, Antoinette
AU - Dalton, Desire L.
AU - Vermaak, Elaine
AU - Paterson, Ian C.
AU - Dobrynin, Pavel
AU - Sitam, Frankie Thomas
AU - Rovie-Ryan, Jeffrine J.
AU - Johnson, Warren E.
AU - Yusoff, Aini Mohamed
AU - Luo, Shu-Jin
AU - Karuppannan, Kayal Vizi
AU - Fang, Gang
AU - Zheng, Deyou
AU - Gerstein, Mark B.
AU - Lipovich, Leonard
AU - O'Brien, Stephen J.
AU - Wong, Guat Jah
PY - 2016
Y1 - 2016
N2 - Pangolins, unique mammals with scales over most of their body, no teeth, poor vision, and an acute olfactory system, comprise the only placental order (Pholidota) without a whole-genome map. To investigate pangolin biology and evolution, we developed genome assemblies of the Malayan (Manis javanica) and Chinese (M. pentadactyla) pangolins. Strikingly, we found that interferon epsilon (IFNE), exclusively expressed in epithelial cells and important in skin and mucosal immunity, is pseudogenized in all African and Asian pangolin species that we examined, perhaps impacting resistance to infection. We propose that scale development was an innovation that provided protection against injuries or stress and reduced pangolin vulnerability to infection. Further evidence of specialized adaptations was evident from positively selected genes involving immunity-related pathways, inflammation, energy storage and metabolism, muscular and nervous systems, and scale/hair development. Olfactory receptor gene families are signif
AB - Pangolins, unique mammals with scales over most of their body, no teeth, poor vision, and an acute olfactory system, comprise the only placental order (Pholidota) without a whole-genome map. To investigate pangolin biology and evolution, we developed genome assemblies of the Malayan (Manis javanica) and Chinese (M. pentadactyla) pangolins. Strikingly, we found that interferon epsilon (IFNE), exclusively expressed in epithelial cells and important in skin and mucosal immunity, is pseudogenized in all African and Asian pangolin species that we examined, perhaps impacting resistance to infection. We propose that scale development was an innovation that provided protection against injuries or stress and reduced pangolin vulnerability to infection. Further evidence of specialized adaptations was evident from positively selected genes involving immunity-related pathways, inflammation, energy storage and metabolism, muscular and nervous systems, and scale/hair development. Olfactory receptor gene families are signif
U2 - 10.1101/gr.203521.115
DO - 10.1101/gr.203521.115
M3 - Article
VL - 26
JO - Genome Research
JF - Genome Research
SN - 1088-9051
IS - 10
ER -
ID: 7966688