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Oxidative modification of human plasma blood proteins in the aged patients with vascular dementia. / Dubinina, E. E.; Konovalov, P. V.; Soliternova, I. B.; Zybina, N. N.; Kovrugina, S. V.; Baklanova, M. Yu; Morozova, M. G.; Leonova, N. V.; Kudrjashova, O. A.

в: Ukrainian biochemical journal, Том 73, № 1, 01.01.2001, стр. 130-132.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Dubinina, EE, Konovalov, PV, Soliternova, IB, Zybina, NN, Kovrugina, SV, Baklanova, MY, Morozova, MG, Leonova, NV & Kudrjashova, OA 2001, 'Oxidative modification of human plasma blood proteins in the aged patients with vascular dementia', Ukrainian biochemical journal, Том. 73, № 1, стр. 130-132.

APA

Dubinina, E. E., Konovalov, P. V., Soliternova, I. B., Zybina, N. N., Kovrugina, S. V., Baklanova, M. Y., Morozova, M. G., Leonova, N. V., & Kudrjashova, O. A. (2001). Oxidative modification of human plasma blood proteins in the aged patients with vascular dementia. Ukrainian biochemical journal, 73(1), 130-132.

Vancouver

Dubinina EE, Konovalov PV, Soliternova IB, Zybina NN, Kovrugina SV, Baklanova MY и пр. Oxidative modification of human plasma blood proteins in the aged patients with vascular dementia. Ukrainian biochemical journal. 2001 Янв. 1;73(1):130-132.

Author

Dubinina, E. E. ; Konovalov, P. V. ; Soliternova, I. B. ; Zybina, N. N. ; Kovrugina, S. V. ; Baklanova, M. Yu ; Morozova, M. G. ; Leonova, N. V. ; Kudrjashova, O. A. / Oxidative modification of human plasma blood proteins in the aged patients with vascular dementia. в: Ukrainian biochemical journal. 2001 ; Том 73, № 1. стр. 130-132.

BibTeX

@article{2f2604805e9a4aee92d963c4db14f749,
title = "Oxidative modification of human plasma blood proteins in the aged patients with vascular dementia",
abstract = "We examined the spontaneous and metal-ion-catalyzed oxidative modification plasma blood proteins in the group of healthy adults and elderly ones and patients with vascular dementia (mild and severe). We determined the spectrophotometric measurement of 2,4-dinitrophenylhydrazone derivatives formed by reactions with protein carbonyls. The level of metal-ion-catalyzed oxidation proteins in the aged patients both with and without dementia was high in comparison to the healthy adults. The patients with severe dementia showed lower amount of 2,4-dinitrophenylhydrazone derivaties. Low levels of metal-ion-catalysed prote{\`i}n oxidation strongly correlated with the degree of psychoorganic disturbances. The elderly persons with both and without dementia showed a high level of plasma nonenzymatic H2O2 scavenging in comparison with the healthy adult ones. We discovered an imbalance between enzymatic and nonenzymatic components of the antioxidant system. The latter indicates that the oxidative modification of brain tissue proteins probably plays an important role in aging and mental disorders.",
keywords = "Aged patients, Antioxidant system, Blood, Oxidative modification of proteins, Vascular dementia",
author = "Dubinina, {E. E.} and Konovalov, {P. V.} and Soliternova, {I. B.} and Zybina, {N. N.} and Kovrugina, {S. V.} and Baklanova, {M. Yu} and Morozova, {M. G.} and Leonova, {N. V.} and Kudrjashova, {O. A.}",
year = "2001",
month = jan,
day = "1",
language = "English",
volume = "73",
pages = "130--132",
journal = "Ukrainian biochemical journal",
issn = "2409-4943",
publisher = "Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine (NASU)",
number = "1",

}

RIS

TY - JOUR

T1 - Oxidative modification of human plasma blood proteins in the aged patients with vascular dementia

AU - Dubinina, E. E.

AU - Konovalov, P. V.

AU - Soliternova, I. B.

AU - Zybina, N. N.

AU - Kovrugina, S. V.

AU - Baklanova, M. Yu

AU - Morozova, M. G.

AU - Leonova, N. V.

AU - Kudrjashova, O. A.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - We examined the spontaneous and metal-ion-catalyzed oxidative modification plasma blood proteins in the group of healthy adults and elderly ones and patients with vascular dementia (mild and severe). We determined the spectrophotometric measurement of 2,4-dinitrophenylhydrazone derivatives formed by reactions with protein carbonyls. The level of metal-ion-catalyzed oxidation proteins in the aged patients both with and without dementia was high in comparison to the healthy adults. The patients with severe dementia showed lower amount of 2,4-dinitrophenylhydrazone derivaties. Low levels of metal-ion-catalysed proteìn oxidation strongly correlated with the degree of psychoorganic disturbances. The elderly persons with both and without dementia showed a high level of plasma nonenzymatic H2O2 scavenging in comparison with the healthy adult ones. We discovered an imbalance between enzymatic and nonenzymatic components of the antioxidant system. The latter indicates that the oxidative modification of brain tissue proteins probably plays an important role in aging and mental disorders.

AB - We examined the spontaneous and metal-ion-catalyzed oxidative modification plasma blood proteins in the group of healthy adults and elderly ones and patients with vascular dementia (mild and severe). We determined the spectrophotometric measurement of 2,4-dinitrophenylhydrazone derivatives formed by reactions with protein carbonyls. The level of metal-ion-catalyzed oxidation proteins in the aged patients both with and without dementia was high in comparison to the healthy adults. The patients with severe dementia showed lower amount of 2,4-dinitrophenylhydrazone derivaties. Low levels of metal-ion-catalysed proteìn oxidation strongly correlated with the degree of psychoorganic disturbances. The elderly persons with both and without dementia showed a high level of plasma nonenzymatic H2O2 scavenging in comparison with the healthy adult ones. We discovered an imbalance between enzymatic and nonenzymatic components of the antioxidant system. The latter indicates that the oxidative modification of brain tissue proteins probably plays an important role in aging and mental disorders.

KW - Aged patients

KW - Antioxidant system

KW - Blood

KW - Oxidative modification of proteins

KW - Vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=0347084877&partnerID=8YFLogxK

M3 - Article

C2 - 11599417

AN - SCOPUS:0347084877

VL - 73

SP - 130

EP - 132

JO - Ukrainian biochemical journal

JF - Ukrainian biochemical journal

SN - 2409-4943

IS - 1

ER -

ID: 125110325