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Ordinary differential equations and boolean networks in application to modelling of 6-mercaptopurine metabolism. / Lavrova, Anastasia I.; Postnikov, Eugene B.; Zyubin, Andrey Yu; Babak, Svetlana V.

в: Royal Society Open Science, Том 4, № 4, 01.04.2017.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

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Lavrova, Anastasia I. ; Postnikov, Eugene B. ; Zyubin, Andrey Yu ; Babak, Svetlana V. / Ordinary differential equations and boolean networks in application to modelling of 6-mercaptopurine metabolism. в: Royal Society Open Science. 2017 ; Том 4, № 4.

BibTeX

@article{0255ff65cc684edc8482d4242b380387,
title = "Ordinary differential equations and boolean networks in application to modelling of 6-mercaptopurine metabolism",
abstract = "We consider two approaches to modelling the cell metabolism of 6-mercaptopurine, one of the important chemotherapy drugs used for treating acute lymphocytic leukaemia: kinetic ordinary differential equations, and Boolean networks supplied with one controlling node, which takes continual values. We analyse their interplay with respect to taking into account ATP concentration as a key parameter of switching between different pathways. It is shown that the Boolean networks, which allow avoiding the complexity of general kinetic modelling, preserve the possibility of reproducing the principal switching mechanism.",
keywords = "Boolean networks, Drug metabolism, Kinetic modelling",
author = "Lavrova, {Anastasia I.} and Postnikov, {Eugene B.} and Zyubin, {Andrey Yu} and Babak, {Svetlana V.}",
year = "2017",
month = apr,
day = "1",
doi = "10.1098/rsos.160872",
language = "English",
volume = "4",
journal = "Royal Society Open Science",
issn = "2054-5703",
publisher = "The Royal Society",
number = "4",

}

RIS

TY - JOUR

T1 - Ordinary differential equations and boolean networks in application to modelling of 6-mercaptopurine metabolism

AU - Lavrova, Anastasia I.

AU - Postnikov, Eugene B.

AU - Zyubin, Andrey Yu

AU - Babak, Svetlana V.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - We consider two approaches to modelling the cell metabolism of 6-mercaptopurine, one of the important chemotherapy drugs used for treating acute lymphocytic leukaemia: kinetic ordinary differential equations, and Boolean networks supplied with one controlling node, which takes continual values. We analyse their interplay with respect to taking into account ATP concentration as a key parameter of switching between different pathways. It is shown that the Boolean networks, which allow avoiding the complexity of general kinetic modelling, preserve the possibility of reproducing the principal switching mechanism.

AB - We consider two approaches to modelling the cell metabolism of 6-mercaptopurine, one of the important chemotherapy drugs used for treating acute lymphocytic leukaemia: kinetic ordinary differential equations, and Boolean networks supplied with one controlling node, which takes continual values. We analyse their interplay with respect to taking into account ATP concentration as a key parameter of switching between different pathways. It is shown that the Boolean networks, which allow avoiding the complexity of general kinetic modelling, preserve the possibility of reproducing the principal switching mechanism.

KW - Boolean networks

KW - Drug metabolism

KW - Kinetic modelling

UR - http://www.scopus.com/inward/record.url?scp=85017617403&partnerID=8YFLogxK

U2 - 10.1098/rsos.160872

DO - 10.1098/rsos.160872

M3 - Article

AN - SCOPUS:85017617403

VL - 4

JO - Royal Society Open Science

JF - Royal Society Open Science

SN - 2054-5703

IS - 4

ER -

ID: 27612111