Standard

Optimal chemotherapy regimens : Influence of tumours on normal cells and several toxicity constraints. / Matveev, A. S.; Savkin, A. V.

в: IMA Journal of Mathemathics Applied in Medicine and Biology, Том 18, № 1, 21.05.2001, стр. 25-40.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Matveev, AS & Savkin, AV 2001, 'Optimal chemotherapy regimens: Influence of tumours on normal cells and several toxicity constraints', IMA Journal of Mathemathics Applied in Medicine and Biology, Том. 18, № 1, стр. 25-40.

APA

Matveev, A. S., & Savkin, A. V. (2001). Optimal chemotherapy regimens: Influence of tumours on normal cells and several toxicity constraints. IMA Journal of Mathemathics Applied in Medicine and Biology, 18(1), 25-40.

Vancouver

Matveev AS, Savkin AV. Optimal chemotherapy regimens: Influence of tumours on normal cells and several toxicity constraints. IMA Journal of Mathemathics Applied in Medicine and Biology. 2001 Май 21;18(1):25-40.

Author

Matveev, A. S. ; Savkin, A. V. / Optimal chemotherapy regimens : Influence of tumours on normal cells and several toxicity constraints. в: IMA Journal of Mathemathics Applied in Medicine and Biology. 2001 ; Том 18, № 1. стр. 25-40.

BibTeX

@article{12892b832cb24e3f81a8148b76d9f39d,
title = "Optimal chemotherapy regimens: Influence of tumours on normal cells and several toxicity constraints",
abstract = "Cancer chemotherapy for the case of one drug is studied. The negative and inhibiting effect of the tumour on normal cells is taken into account. Under certain assumptions, we determine the optimal regimen that minimizes the tumour burden at the end of a fixed period of therapy while maintaining certain normal cell populations above prescribed levels. More precisely, it is demonstrated that the optimal strategy corresponds to injection of the drug at the maximal rate.",
keywords = "Cancer chemotherapy, Normal cells, Optimal regimen, Tumours",
author = "Matveev, {A. S.} and Savkin, {A. V.}",
year = "2001",
month = may,
day = "21",
language = "English",
volume = "18",
pages = "25--40",
journal = "Mathematical Medicine and Biology",
issn = "1477-8599",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Optimal chemotherapy regimens

T2 - Influence of tumours on normal cells and several toxicity constraints

AU - Matveev, A. S.

AU - Savkin, A. V.

PY - 2001/5/21

Y1 - 2001/5/21

N2 - Cancer chemotherapy for the case of one drug is studied. The negative and inhibiting effect of the tumour on normal cells is taken into account. Under certain assumptions, we determine the optimal regimen that minimizes the tumour burden at the end of a fixed period of therapy while maintaining certain normal cell populations above prescribed levels. More precisely, it is demonstrated that the optimal strategy corresponds to injection of the drug at the maximal rate.

AB - Cancer chemotherapy for the case of one drug is studied. The negative and inhibiting effect of the tumour on normal cells is taken into account. Under certain assumptions, we determine the optimal regimen that minimizes the tumour burden at the end of a fixed period of therapy while maintaining certain normal cell populations above prescribed levels. More precisely, it is demonstrated that the optimal strategy corresponds to injection of the drug at the maximal rate.

KW - Cancer chemotherapy

KW - Normal cells

KW - Optimal regimen

KW - Tumours

UR - http://www.scopus.com/inward/record.url?scp=0035001996&partnerID=8YFLogxK

M3 - Article

C2 - 11339336

AN - SCOPUS:0035001996

VL - 18

SP - 25

EP - 40

JO - Mathematical Medicine and Biology

JF - Mathematical Medicine and Biology

SN - 1477-8599

IS - 1

ER -

ID: 50909674