Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Opening up new horizons for psychiatric genetics in the Russian Federation : moving toward a national consortium. / Fedorenko, Olga Yu; Golimbet, Vera E.; Levchenko, Аnastasia; Gainetdinov, Raul R.; Semke, Arkady V.; Simutkin, German G.; Gareeva, Аnna E.; Glotov, Аndrey S.; Gryaznova, Anna; Iourov, Ivan Y.; Krupitsky, Evgeny M.; Lebedev, Igor N.; Mazo, Galina E.; Kaleda, Vasily G.; Abramova, Lilia I.; Oleichik, Igor V.; Nasykhova, Yulia A.; Nasyrova, Regina F.; Nikolishin, Anton E.; Kasyanov, Evgeny D.; Rukavishnikov, Grigory V.; Timerbulatov, Ilgiz F.; Brodyansky, Vadim M.; Vorsanova, Svetlana G.; Yurov, Yury B.; Zhilyaeva, Tatyana V.; Sergeeva, Anzhelika V.; Blokhina, Elena A.; Zvartau, Edwin E.; Blagonravova, Anna S.; Aftanas, Lyubomir I.; Bokhan, Nikolay; Kekelidze, Zurab I.; Klimenko, Tatyana V.; Anokhina, Irina P.; Khusnutdinova, Elza K.; Klyushnik, Tatyana P.; Neznanov, Nikolay G.; Stepanov, Vadim A.; Schulze, Thomas G.; Kibitov, Аleksandr.
в: Molecular Psychiatry, Том 24, № 8, 01.08.2019, стр. 1099-1111.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Opening up new horizons for psychiatric genetics in the Russian Federation
T2 - moving toward a national consortium
AU - Fedorenko, Olga Yu
AU - Golimbet, Vera E.
AU - Levchenko, Аnastasia
AU - Gainetdinov, Raul R.
AU - Semke, Arkady V.
AU - Simutkin, German G.
AU - Gareeva, Аnna E.
AU - Glotov, Аndrey S.
AU - Gryaznova, Anna
AU - Iourov, Ivan Y.
AU - Krupitsky, Evgeny M.
AU - Lebedev, Igor N.
AU - Mazo, Galina E.
AU - Kaleda, Vasily G.
AU - Abramova, Lilia I.
AU - Oleichik, Igor V.
AU - Nasykhova, Yulia A.
AU - Nasyrova, Regina F.
AU - Nikolishin, Anton E.
AU - Kasyanov, Evgeny D.
AU - Rukavishnikov, Grigory V.
AU - Timerbulatov, Ilgiz F.
AU - Brodyansky, Vadim M.
AU - Vorsanova, Svetlana G.
AU - Yurov, Yury B.
AU - Zhilyaeva, Tatyana V.
AU - Sergeeva, Anzhelika V.
AU - Blokhina, Elena A.
AU - Zvartau, Edwin E.
AU - Blagonravova, Anna S.
AU - Aftanas, Lyubomir I.
AU - Bokhan, Nikolay
AU - Kekelidze, Zurab I.
AU - Klimenko, Tatyana V.
AU - Anokhina, Irina P.
AU - Khusnutdinova, Elza K.
AU - Klyushnik, Tatyana P.
AU - Neznanov, Nikolay G.
AU - Stepanov, Vadim A.
AU - Schulze, Thomas G.
AU - Kibitov, Аleksandr
PY - 2019/8/1
Y1 - 2019/8/1
N2 - We provide an overview of the recent achievements in psychiatric genetics research in the Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, and pharmacogenetic studies, with an emphasis on genome-wide association studies. The genetic backgrounds of mental illnesses in the polyethnic and multicultural population of the Russian Federation are still understudied. Furthermore, genetic, genomic, and pharmacogenetic data from the Russian Federation are not adequately represented in the international scientific literature, are currently not available for meta-analyses and have never been compared with data from other populations. Most of these problems cannot be solved by individual centers working in isolation but warrant a truly collaborative effort that brings together all the major psychiatric genetic research centers in the Russian Federation in a national consortium. For this reason, we have established the Russian National Consortium for Psychiatric Genetics (RNCPG) with the aim to strengthen the power and rigor of psychiatric genetics research in the Russian Federation and enhance the international compatibility of this research. The consortium is set up as an open organization that will facilitate collaborations on complex biomedical research projects in human mental health in the Russian Federation and abroad. These projects will include genotyping, sequencing, transcriptome and epigenome analysis, metabolomics, and a wide array of other state-of-the-art analyses. Here, we discuss the challenges we face and the approaches we will take to unlock the huge potential that the Russian Federation holds for the worldwide psychiatric genetics community.
AB - We provide an overview of the recent achievements in psychiatric genetics research in the Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, and pharmacogenetic studies, with an emphasis on genome-wide association studies. The genetic backgrounds of mental illnesses in the polyethnic and multicultural population of the Russian Federation are still understudied. Furthermore, genetic, genomic, and pharmacogenetic data from the Russian Federation are not adequately represented in the international scientific literature, are currently not available for meta-analyses and have never been compared with data from other populations. Most of these problems cannot be solved by individual centers working in isolation but warrant a truly collaborative effort that brings together all the major psychiatric genetic research centers in the Russian Federation in a national consortium. For this reason, we have established the Russian National Consortium for Psychiatric Genetics (RNCPG) with the aim to strengthen the power and rigor of psychiatric genetics research in the Russian Federation and enhance the international compatibility of this research. The consortium is set up as an open organization that will facilitate collaborations on complex biomedical research projects in human mental health in the Russian Federation and abroad. These projects will include genotyping, sequencing, transcriptome and epigenome analysis, metabolomics, and a wide array of other state-of-the-art analyses. Here, we discuss the challenges we face and the approaches we will take to unlock the huge potential that the Russian Federation holds for the worldwide psychiatric genetics community.
KW - ALZHEIMERS-DISEASE
KW - PHARMACOGENETIC MARKERS
KW - PARANOID SCHIZOPHRENIA
KW - TARDIVE-DYSKINESIA
KW - RECEPTOR GENES
KW - POLYMORPHISM
KW - ASSOCIATION
KW - BRAIN
KW - ANEUPLOIDY
KW - DRUG
UR - http://www.scopus.com/inward/record.url?scp=85060472069&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/opening-up-new-horizons-psychiatric-genetics-russian-federation-moving-toward-national-consortium
U2 - 10.1038/s41380-019-0354-z
DO - 10.1038/s41380-019-0354-z
M3 - Article
C2 - 30664668
VL - 24
SP - 1099
EP - 1111
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
IS - 8
ER -
ID: 38194977