Standard

Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently. / Makashov, A.A.; Malov, S.V.; Kozlov, A.P.

в: Scientific Reports, Том 9, № 1, 16410, 01.12.2019.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Makashov, AA, Malov, SV & Kozlov, AP 2019, 'Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently', Scientific Reports, Том. 9, № 1, 16410. https://doi.org/10.1038/s41598-019-52835-w

APA

Makashov, A. A., Malov, S. V., & Kozlov, A. P. (2019). Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently. Scientific Reports, 9(1), [16410]. https://doi.org/10.1038/s41598-019-52835-w

Vancouver

Makashov AA, Malov SV, Kozlov AP. Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently. Scientific Reports. 2019 Дек. 1;9(1). 16410. https://doi.org/10.1038/s41598-019-52835-w

Author

Makashov, A.A. ; Malov, S.V. ; Kozlov, A.P. / Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently. в: Scientific Reports. 2019 ; Том 9, № 1.

BibTeX

@article{771b29552d0a40f988be38541ebd2b34,
title = "Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently",
abstract = "Earlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggest calling such genes Tumor Specifically Expressed, Evolutionarily New (TSEEN) genes. In this paper we performed a study of the evolutionary ages of different classes of human genes, using homology searches in genomes of different taxa in human lineage. We discovered that different classes of human genes have different evolutionary ages and confirmed the existence of TSEEN gene classes. On the other hand, we found that oncogenes, tumor-suppressor genes and differentiation genes are among the oldest gene classes in humans and their evolution occurs concurrently. These findings confirm non-trivial predictions made by our hypothesis of the possible evolutionary role of hereditary tumors. The results may be important for better understanding of tumor biology. TSEEN genes may become the best tumor markers.",
keywords = "Evolution, Oncogenes, Tumors",
author = "A.A. Makashov and S.V. Malov and A.P. Kozlov",
note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41598-019-52835-w",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently

AU - Makashov, A.A.

AU - Malov, S.V.

AU - Kozlov, A.P.

N1 - Publisher Copyright: © 2019, The Author(s).

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Earlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggest calling such genes Tumor Specifically Expressed, Evolutionarily New (TSEEN) genes. In this paper we performed a study of the evolutionary ages of different classes of human genes, using homology searches in genomes of different taxa in human lineage. We discovered that different classes of human genes have different evolutionary ages and confirmed the existence of TSEEN gene classes. On the other hand, we found that oncogenes, tumor-suppressor genes and differentiation genes are among the oldest gene classes in humans and their evolution occurs concurrently. These findings confirm non-trivial predictions made by our hypothesis of the possible evolutionary role of hereditary tumors. The results may be important for better understanding of tumor biology. TSEEN genes may become the best tumor markers.

AB - Earlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggest calling such genes Tumor Specifically Expressed, Evolutionarily New (TSEEN) genes. In this paper we performed a study of the evolutionary ages of different classes of human genes, using homology searches in genomes of different taxa in human lineage. We discovered that different classes of human genes have different evolutionary ages and confirmed the existence of TSEEN gene classes. On the other hand, we found that oncogenes, tumor-suppressor genes and differentiation genes are among the oldest gene classes in humans and their evolution occurs concurrently. These findings confirm non-trivial predictions made by our hypothesis of the possible evolutionary role of hereditary tumors. The results may be important for better understanding of tumor biology. TSEEN genes may become the best tumor markers.

KW - Evolution

KW - Oncogenes

KW - Tumors

UR - http://www.scopus.com/inward/record.url?scp=85074862771&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/oncogenes-tumor-suppressor-differentiation-genes-represent-oldest-human-gene-classes-evolve-concurre

U2 - 10.1038/s41598-019-52835-w

DO - 10.1038/s41598-019-52835-w

M3 - Article

C2 - 31712655

AN - SCOPUS:85074862771

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 16410

ER -

ID: 48701729