Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
O kompensatornoǐ funktsii GAMK-shunta v énergicheskom metabolizme mozga pri dozirovannoǐ cherepno-mozgovoǐ travme u krys. / Rozanov, V. A.; Tsepkolenko, V. A.; Levitskiǐ, M. V.; Galich, I. M.; Promyslov, M. S.
в: Zhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko, № 5, 01.09.1988, стр. 11-15.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - O kompensatornoǐ funktsii GAMK-shunta v énergicheskom metabolizme mozga pri dozirovannoǐ cherepno-mozgovoǐ travme u krys.
AU - Rozanov, V. A.
AU - Tsepkolenko, V. A.
AU - Levitskiǐ, M. V.
AU - Galich, I. M.
AU - Promyslov, M. S.
PY - 1988/9/1
Y1 - 1988/9/1
N2 - A severe compression craniocerebral trauma was induced in rats under short-term halothane anesthesia. The activity of pyruvate and 2-oxoglutarate dehydrogenase complexes reduced significantly in the tissue of the damaged hemisphere, ALT activity increased sharply, AST activity grew slowly, the production of GABA in the glutamate decarboxylase reaction was slightly inhibited and its utilization in the GABA transaminase reaction was clearly accelerated. The GABA level in the nerve tissue showed a tendency to reduce, while the glutamate level had a tendency to increase. The observed changes are evidence that the inclusion of the GABA skeleton in the reaction of further oxidation intensifies, which may be of significance in compensation of the transport of the energetically oxidizing succinate and, possibly, in the formation of endogenous GABA possessing a stress-relieving effect.
AB - A severe compression craniocerebral trauma was induced in rats under short-term halothane anesthesia. The activity of pyruvate and 2-oxoglutarate dehydrogenase complexes reduced significantly in the tissue of the damaged hemisphere, ALT activity increased sharply, AST activity grew slowly, the production of GABA in the glutamate decarboxylase reaction was slightly inhibited and its utilization in the GABA transaminase reaction was clearly accelerated. The GABA level in the nerve tissue showed a tendency to reduce, while the glutamate level had a tendency to increase. The observed changes are evidence that the inclusion of the GABA skeleton in the reaction of further oxidation intensifies, which may be of significance in compensation of the transport of the energetically oxidizing succinate and, possibly, in the formation of endogenous GABA possessing a stress-relieving effect.
UR - http://www.scopus.com/inward/record.url?scp=0024085753&partnerID=8YFLogxK
M3 - статья
C2 - 2905562
AN - SCOPUS:0024085753
SP - 11
EP - 15
JO - ЖУРНАЛ ВОПРОСЫ НЕЙРОХИРУРГИИ ИМ. Н.Н. БУРДЕНКО
JF - ЖУРНАЛ ВОПРОСЫ НЕЙРОХИРУРГИИ ИМ. Н.Н. БУРДЕНКО
SN - 0042-8817
IS - 5
ER -
ID: 42770556