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Nuclear lamins regulate osteogenic differentiation of mesenchymal stem cells. / Bogdanova, M. A.; Gudkova, A. Y.; Zabirnik, A. S.; Ignatieva, E. V.; Dmitrieva, R. I.; Smolina, N. A.; Kostareva, A. A.; Malashicheva, A. B.

в: Cell and Tissue Biology, Том 8, № 4, 01.01.2014, стр. 292-298.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Bogdanova, MA, Gudkova, AY, Zabirnik, AS, Ignatieva, EV, Dmitrieva, RI, Smolina, NA, Kostareva, AA & Malashicheva, AB 2014, 'Nuclear lamins regulate osteogenic differentiation of mesenchymal stem cells', Cell and Tissue Biology, Том. 8, № 4, стр. 292-298. https://doi.org/10.1134/S1990519X14040026

APA

Bogdanova, M. A., Gudkova, A. Y., Zabirnik, A. S., Ignatieva, E. V., Dmitrieva, R. I., Smolina, N. A., Kostareva, A. A., & Malashicheva, A. B. (2014). Nuclear lamins regulate osteogenic differentiation of mesenchymal stem cells. Cell and Tissue Biology, 8(4), 292-298. https://doi.org/10.1134/S1990519X14040026

Vancouver

Bogdanova MA, Gudkova AY, Zabirnik AS, Ignatieva EV, Dmitrieva RI, Smolina NA и пр. Nuclear lamins regulate osteogenic differentiation of mesenchymal stem cells. Cell and Tissue Biology. 2014 Янв. 1;8(4):292-298. https://doi.org/10.1134/S1990519X14040026

Author

Bogdanova, M. A. ; Gudkova, A. Y. ; Zabirnik, A. S. ; Ignatieva, E. V. ; Dmitrieva, R. I. ; Smolina, N. A. ; Kostareva, A. A. ; Malashicheva, A. B. / Nuclear lamins regulate osteogenic differentiation of mesenchymal stem cells. в: Cell and Tissue Biology. 2014 ; Том 8, № 4. стр. 292-298.

BibTeX

@article{67dcbda40d5d46b686995c8d8aec989f,
title = "Nuclear lamins regulate osteogenic differentiation of mesenchymal stem cells",
abstract = "Absract: Nuclear lamins are the main proteins of the nuclear envelope providing nuclear-membrane strength. Recently, it became clear that lamins in cells play not only a structural role, but are also involved in regulation of gene expression. The LMNA gene encodes lamin A or C depending on the synthesizing splicing variant. The best-known LMNA mutation causes severe disorders in development known as progeria (premature aging syndrome). The disease is of rare occurrence. More frequently, point mutations in LMNA gene encoding lamin A/C result in so-called laminopathies, these diseases manifesting as tissue damage, mostly in tissues of mesenchymal origin. The mutations manifest in a tissue-specific manner: particular mutations always display the same disease phenotype. The nature of this phenomenon, as well as the mechanisms by which lamins regulate cell differentiation remain poorly understood. The aim of this study was to investigate the effect of different LMNA mutations on human mesenchimal stem cell (MSC) osteogenic differentiation and explore the possible interaction of lamins and Notch signaling pathway. We modified human MSCs with mutant LMNA bearing known mutations with tissue specific phenotype associated with different laminopathies. Differentiation was evaluated 21 days after its induction by number of differentiated cells, as well as by the expression level of specific osteogenic markers SPP, IBSP, and BGLAP. Some mutations enhance differentiation whereas others decrease its level. These findings support the notion that lamin A/C is involved in the regulation of MMSC differentiation. Introduction of mutant LMNA forms together with the activated Notch domain modified the expression of HEY1, a major target of Notch signaling. Thereby, one of the mechanisms involved in the regulation of MSC differentiation may be the interaction of lamins A/C with components of Notch signaling.",
keywords = "lamins A/C, multipotent mesenchymal stromal cells, osteogenic differentiation",
author = "Bogdanova, {M. A.} and Gudkova, {A. Y.} and Zabirnik, {A. S.} and Ignatieva, {E. V.} and Dmitrieva, {R. I.} and Smolina, {N. A.} and Kostareva, {A. A.} and Malashicheva, {A. B.}",
year = "2014",
month = jan,
day = "1",
doi = "10.1134/S1990519X14040026",
language = "English",
volume = "8",
pages = "292--298",
journal = "Cell and Tissue Biology",
issn = "1990-519X",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "4",

}

RIS

TY - JOUR

T1 - Nuclear lamins regulate osteogenic differentiation of mesenchymal stem cells

AU - Bogdanova, M. A.

AU - Gudkova, A. Y.

AU - Zabirnik, A. S.

AU - Ignatieva, E. V.

AU - Dmitrieva, R. I.

AU - Smolina, N. A.

AU - Kostareva, A. A.

AU - Malashicheva, A. B.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Absract: Nuclear lamins are the main proteins of the nuclear envelope providing nuclear-membrane strength. Recently, it became clear that lamins in cells play not only a structural role, but are also involved in regulation of gene expression. The LMNA gene encodes lamin A or C depending on the synthesizing splicing variant. The best-known LMNA mutation causes severe disorders in development known as progeria (premature aging syndrome). The disease is of rare occurrence. More frequently, point mutations in LMNA gene encoding lamin A/C result in so-called laminopathies, these diseases manifesting as tissue damage, mostly in tissues of mesenchymal origin. The mutations manifest in a tissue-specific manner: particular mutations always display the same disease phenotype. The nature of this phenomenon, as well as the mechanisms by which lamins regulate cell differentiation remain poorly understood. The aim of this study was to investigate the effect of different LMNA mutations on human mesenchimal stem cell (MSC) osteogenic differentiation and explore the possible interaction of lamins and Notch signaling pathway. We modified human MSCs with mutant LMNA bearing known mutations with tissue specific phenotype associated with different laminopathies. Differentiation was evaluated 21 days after its induction by number of differentiated cells, as well as by the expression level of specific osteogenic markers SPP, IBSP, and BGLAP. Some mutations enhance differentiation whereas others decrease its level. These findings support the notion that lamin A/C is involved in the regulation of MMSC differentiation. Introduction of mutant LMNA forms together with the activated Notch domain modified the expression of HEY1, a major target of Notch signaling. Thereby, one of the mechanisms involved in the regulation of MSC differentiation may be the interaction of lamins A/C with components of Notch signaling.

AB - Absract: Nuclear lamins are the main proteins of the nuclear envelope providing nuclear-membrane strength. Recently, it became clear that lamins in cells play not only a structural role, but are also involved in regulation of gene expression. The LMNA gene encodes lamin A or C depending on the synthesizing splicing variant. The best-known LMNA mutation causes severe disorders in development known as progeria (premature aging syndrome). The disease is of rare occurrence. More frequently, point mutations in LMNA gene encoding lamin A/C result in so-called laminopathies, these diseases manifesting as tissue damage, mostly in tissues of mesenchymal origin. The mutations manifest in a tissue-specific manner: particular mutations always display the same disease phenotype. The nature of this phenomenon, as well as the mechanisms by which lamins regulate cell differentiation remain poorly understood. The aim of this study was to investigate the effect of different LMNA mutations on human mesenchimal stem cell (MSC) osteogenic differentiation and explore the possible interaction of lamins and Notch signaling pathway. We modified human MSCs with mutant LMNA bearing known mutations with tissue specific phenotype associated with different laminopathies. Differentiation was evaluated 21 days after its induction by number of differentiated cells, as well as by the expression level of specific osteogenic markers SPP, IBSP, and BGLAP. Some mutations enhance differentiation whereas others decrease its level. These findings support the notion that lamin A/C is involved in the regulation of MMSC differentiation. Introduction of mutant LMNA forms together with the activated Notch domain modified the expression of HEY1, a major target of Notch signaling. Thereby, one of the mechanisms involved in the regulation of MSC differentiation may be the interaction of lamins A/C with components of Notch signaling.

KW - lamins A/C

KW - multipotent mesenchymal stromal cells

KW - osteogenic differentiation

UR - http://www.scopus.com/inward/record.url?scp=84906280662&partnerID=8YFLogxK

U2 - 10.1134/S1990519X14040026

DO - 10.1134/S1990519X14040026

M3 - Article

AN - SCOPUS:84906280662

VL - 8

SP - 292

EP - 298

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - 4

ER -

ID: 35808166