TY - JOUR

T1 - Novel translational rat models of dopamine transporter deficiency

AU - Leo, Damiana

AU - Sukhanov, Ilya

AU - Gainetdinov, Raul R.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Carbosilane dendrimers with 64 and 128 surface Si-Cl bonds were used as coupling reagents for monodisperse poly(butadienyl)lithium. Two series of regular star polybutadienes with 64 and 128 arms were prepd. The arm mol. wt. was varied between 6400 and 72,000. The dil. soln. properties of the stars were detd. in a good solvent (cyclohexane) and in a θ-solvent (dioxane) for polybutadiene. Measurements of radius of gyration (Rg), second virial coeff. (A2), translational diffusion coeff. (D0), and intrinsic viscosity [η] indicate that the isolated stars behave as hard spheres. The ratio of the hydrodynamic radius over the Rg is slightly larger than (5/3)1/2. A comparison including previously made stars with lower functionality showed that the ratio g of av. of Rg2 to av. of Rg2 in infinite dil. soln. went as f-0.73 in the good solvent and f-0.64 in the θ-solvent with f donating the functionality of the star calcd. as the ratio Mw for star to Mn for arm. The former result is in good agreement with the Daoud-Cotton scaling model of starts. The latter dependence is stronger than the theory predicts: gθ went as f-0.5. A recent quant. model developed by Gast et al. for polymeric micelles is in good agreement with the present exptl. data. Stars with many arms represented good model polymers for polymeric micelles. [on SciFinder(R)]

AB - Carbosilane dendrimers with 64 and 128 surface Si-Cl bonds were used as coupling reagents for monodisperse poly(butadienyl)lithium. Two series of regular star polybutadienes with 64 and 128 arms were prepd. The arm mol. wt. was varied between 6400 and 72,000. The dil. soln. properties of the stars were detd. in a good solvent (cyclohexane) and in a θ-solvent (dioxane) for polybutadiene. Measurements of radius of gyration (Rg), second virial coeff. (A2), translational diffusion coeff. (D0), and intrinsic viscosity [η] indicate that the isolated stars behave as hard spheres. The ratio of the hydrodynamic radius over the Rg is slightly larger than (5/3)1/2. A comparison including previously made stars with lower functionality showed that the ratio g of av. of Rg2 to av. of Rg2 in infinite dil. soln. went as f-0.73 in the good solvent and f-0.64 in the θ-solvent with f donating the functionality of the star calcd. as the ratio Mw for star to Mn for arm. The former result is in good agreement with the Daoud-Cotton scaling model of starts. The latter dependence is stronger than the theory predicts: gθ went as f-0.5. A recent quant. model developed by Gast et al. for polymeric micelles is in good agreement with the present exptl. data. Stars with many arms represented good model polymers for polymeric micelles. [on SciFinder(R)]

KW - MICE

KW - HYPERACTIVITY

UR - http://www.scopus.com/inward/record.url?scp=85055138570&partnerID=8YFLogxK

UR - http://www.nrronline.org/text.asp?2018/13/12/2091/241453

UR - http://www.mendeley.com/research/novel-translational-rat-models-dopamine-transporter-deficiency

U2 - 10.4103/1673-5374.241453

DO - 10.4103/1673-5374.241453

M3 - Review article

AN - SCOPUS:85055138570

VL - 13

SP - 2091

EP - 2093

JO - Neural Regeneration Research

JF - Neural Regeneration Research

SN - 1673-5374

IS - 12

ER -