Novel brominated metabolites from Bryozoa › Научные исследования в СПбГУ

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Novel brominated metabolites from Bryozoa : a functional analysis. / Maltseva, Arina L.; Kotenko, Olga N.; Kutyumov, Vladimir A.; Matvienko, Darya A.; Shavarda, Alexey L.; Winson, Michael K.; Ostrovsky, Andrew N.

в: Natural Product Research, Том 31, № 16, 2017, стр. 1840-1848.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Maltseva, Arina L. ; Kotenko, Olga N. ; Kutyumov, Vladimir A. ; Matvienko, Darya A. ; Shavarda, Alexey L. ; Winson, Michael K. ; Ostrovsky, Andrew N. / Novel brominated metabolites from Bryozoa : a functional analysis. в: Natural Product Research. 2017 ; Том 31, № 16. стр. 1840-1848.

BibTeX

@article{f6ad0d8bd21d408fa7ab3fa471dfb113,

title = "Novel brominated metabolites from Bryozoa: a functional analysis",

abstract = "Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential has been discovered in recent years. Here, we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study, we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumour cell lines. The gradient distribution of this compound within the bryozoan colony was demonstrated using LC-MS-analysis.",

keywords = "Alkaloid, antitumour activity, fungicidal activity, metabolites, natural products, terminoflustrindole",

author = "Maltseva, {Arina L.} and Kotenko, {Olga N.} and Kutyumov, {Vladimir A.} and Matvienko, {Darya A.} and Shavarda, {Alexey L.} and Winson, {Michael K.} and Ostrovsky, {Andrew N.}",

note = "Publisher Copyright: {\textcopyright} 2016 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2017",

doi = "10.1080/14786419.2016.1261344",

language = "English",

volume = "31",

pages = "1840--1848",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor & Francis",

number = "16",

}

RIS

TY - JOUR

T1 - Novel brominated metabolites from Bryozoa

T2 - a functional analysis

AU - Maltseva, Arina L.

AU - Kotenko, Olga N.

AU - Kutyumov, Vladimir A.

AU - Matvienko, Darya A.

AU - Shavarda, Alexey L.

AU - Winson, Michael K.

AU - Ostrovsky, Andrew N.

PY - 2017

Y1 - 2017

N2 - Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential has been discovered in recent years. Here, we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study, we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumour cell lines. The gradient distribution of this compound within the bryozoan colony was demonstrated using LC-MS-analysis.

AB - Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential has been discovered in recent years. Here, we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study, we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumour cell lines. The gradient distribution of this compound within the bryozoan colony was demonstrated using LC-MS-analysis.

KW - Alkaloid

KW - antitumour activity

KW - fungicidal activity

KW - metabolites

KW - natural products

KW - terminoflustrindole

UR - http://www.scopus.com/inward/record.url?scp=84999634773&partnerID=8YFLogxK

U2 - 10.1080/14786419.2016.1261344

DO - 10.1080/14786419.2016.1261344

M3 - Article

C2 - 27897055

VL - 31

SP - 1840

EP - 1848

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

IS - 16

ER -

ID: 7731163

Novel brominated metabolites from Bryozoa: a functional analysis

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