Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Notch signaling in the pathogenesis of thoracic aortic aneurysms : A bridge between embryonic and adult states. / Malashicheva, Anna; Kostina, Aleksandra; Kostareva, Anna; Irtyuga, Olga; Gordeev, Mikhail; Uspensky, Vladimir.
в: Biochimica et Biophysica Acta - Molecular Basis of Disease, Том 1866, № 3, 165631, 01.03.2020.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Notch signaling in the pathogenesis of thoracic aortic aneurysms
T2 - A bridge between embryonic and adult states
AU - Malashicheva, Anna
AU - Kostina, Aleksandra
AU - Kostareva, Anna
AU - Irtyuga, Olga
AU - Gordeev, Mikhail
AU - Uspensky, Vladimir
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Aneurysms of the thoracic aorta are a “silent killer” with no evident clinical signs until the fatal outcome. Molecular and genetic bases of thoracic aortic aneurysms mainly include transforming growth factor beta signaling, smooth muscle contractile units and metabolism genes, and extracellular matrix genes. In recent studies, a role of Notch signaling, among other pathways, has emerged in disease pathogenesis. Notch is a highly conserved signaling pathway that regulates the development and differentiation of many types of tissues and influences major cellular processes such as cell proliferation, differentiation and apoptosis. Mutations in several Notch signaling components have been associated with a number of heart defects, demonstrating an essential role of Notch signaling both in cardiovascular system development and its maintenance during postnatal life. This review discusses the role of Notch signaling in the pathogenesis of thoracic aortic aneurysms considering development and maintenance of the aortic root and how developmental regulations by Notch signaling may influence thoracic aortic aneurysms.
AB - Aneurysms of the thoracic aorta are a “silent killer” with no evident clinical signs until the fatal outcome. Molecular and genetic bases of thoracic aortic aneurysms mainly include transforming growth factor beta signaling, smooth muscle contractile units and metabolism genes, and extracellular matrix genes. In recent studies, a role of Notch signaling, among other pathways, has emerged in disease pathogenesis. Notch is a highly conserved signaling pathway that regulates the development and differentiation of many types of tissues and influences major cellular processes such as cell proliferation, differentiation and apoptosis. Mutations in several Notch signaling components have been associated with a number of heart defects, demonstrating an essential role of Notch signaling both in cardiovascular system development and its maintenance during postnatal life. This review discusses the role of Notch signaling in the pathogenesis of thoracic aortic aneurysms considering development and maintenance of the aortic root and how developmental regulations by Notch signaling may influence thoracic aortic aneurysms.
KW - Notch receptor
KW - CARDIOVASCULAR DEVELOPMENT
KW - HEART DEVELOPMENT
KW - PROMOTES VASCULAR MATURATION
KW - RECEPTOR EXPRESSION
KW - OSTEOGENIC DIFFERENTIATION
KW - SMOOTH-MUSCLE-CELLS
KW - GROWTH-FACTOR
KW - MESENCHYMAL TRANSITION
KW - NEURAL CREST
KW - CARDIAC DEVELOPMENT
UR - http://www.scopus.com/inward/record.url?scp=85076499076&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/495ff1fd-8515-3960-a498-59d8e95ca66c/
U2 - 10.1016/j.bbadis.2019.165631
DO - 10.1016/j.bbadis.2019.165631
M3 - Review article
C2 - 31816439
AN - SCOPUS:85076499076
VL - 1866
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
SN - 0925-4439
IS - 3
M1 - 165631
ER -
ID: 51122545