Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Non-pharmacological and pharmacological approaches for psychiatric disorders : Re-appraisal and insights from zebrafish models. / de Abreu, Murilo S; Giacomini, Ana C V V; Genario, Rafael; Rech, Nathália; Carboni, Júlia; Lakstygal, Anton M; Amstislavskaya, Tamara G; Demin, Konstantin A; Leonard, Brian E; Vlok, Marli; Harvey, Brian H; Piato, Angelo; Barcellos, Leonardo J G; Kalueff, Allan V.
в: Pharmacology, Biochemistry and Behavior, Том 193, 172928, 06.2020, стр. 172928.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Non-pharmacological and pharmacological approaches for psychiatric disorders
T2 - Re-appraisal and insights from zebrafish models
AU - de Abreu, Murilo S
AU - Giacomini, Ana C V V
AU - Genario, Rafael
AU - Rech, Nathália
AU - Carboni, Júlia
AU - Lakstygal, Anton M
AU - Amstislavskaya, Tamara G
AU - Demin, Konstantin A
AU - Leonard, Brian E
AU - Vlok, Marli
AU - Harvey, Brian H
AU - Piato, Angelo
AU - Barcellos, Leonardo J G
AU - Kalueff, Allan V
N1 - Publisher Copyright: © 2020 Elsevier Inc.
PY - 2020/6
Y1 - 2020/6
N2 - Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacotherapy and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.
AB - Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacotherapy and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.
KW - Acute and chronic stress
KW - Animal model
KW - Environmental enrichment
KW - Mental illness
KW - Psychopharmacotherapy
KW - DANIO-RERIO
KW - GENERALIZED ANXIETY DISORDER
KW - ACUTE RESTRAINT STRESS
KW - ENVIRONMENTAL ENRICHMENT
KW - CHRONIC MILD STRESS
KW - ADULT ZEBRAFISH
KW - NEUROTRANSMITTER SYSTEMS
KW - DEPRESSION-LIKE BEHAVIOR
KW - TIME-DEPENDENT SENSITIZATION
KW - ANIMAL-MODELS
UR - http://www.scopus.com/inward/record.url?scp=85083882651&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/01a6c5ca-6063-3528-a97f-027ac91f2a57/
U2 - 10.1016/j.pbb.2020.172928
DO - 10.1016/j.pbb.2020.172928
M3 - Review article
C2 - 32289330
VL - 193
SP - 172928
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
SN - 0091-3057
M1 - 172928
ER -
ID: 53131669