Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Non-natural 2H-azirine-2-carboxylic acids: an expedient synthesis and antimicrobial activity. / Sakharov, Pavel A. ; Koronatov, Alexander N. ; Khlebnikov, Alexander F. ; Novikov, Mikhail S. ; Glukharev, Artem G. ; Rogacheva, Elizaveta V. ; Kraeva, Liudmila A. ; Sharoyko, Vladimir V. ; Tennikova, Tatiana B. ; Rostovskii, Nikolai V. .
в: RSC Advances, Том 9, № 65, 21.11.2019, стр. 9864–9873.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Non-natural 2H-azirine-2-carboxylic acids: an expedient synthesis and antimicrobial activity
AU - Sakharov, Pavel A.
AU - Koronatov, Alexander N.
AU - Khlebnikov, Alexander F.
AU - Novikov, Mikhail S.
AU - Glukharev, Artem G.
AU - Rogacheva, Elizaveta V.
AU - Kraeva, Liudmila A.
AU - Sharoyko, Vladimir V.
AU - Tennikova, Tatiana B.
AU - Rostovskii, Nikolai V.
PY - 2019/11/21
Y1 - 2019/11/21
N2 - Non-natural 2H-azirine-2-carboxylicacidswereobtainedinhighyields by FeCl2-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial activity against ESKAPE pathogens and show a low level of cytotoxicity.
AB - Non-natural 2H-azirine-2-carboxylicacidswereobtainedinhighyields by FeCl2-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial activity against ESKAPE pathogens and show a low level of cytotoxicity.
UR - https://pubs.rsc.org/en/content/articlelanding/2019/ra/c9ra09345a#!divAbstract
M3 - Article
VL - 9
SP - 9864
EP - 9873
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 65
ER -
ID: 49169488