Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Nitric oxide-biochemical marker of tuberculosis pathogenesis. / Dyakova, M. E.; Alekseeva, N. P.; Esmedlyaeva, D. S.; Perova, T. L.; Petrischev, N. N.; Yablonsky, P. K.
в: Tuberculosis and Lung Diseases, Том 95, № 2, 2017, стр. 45-50.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Nitric oxide-biochemical marker of tuberculosis pathogenesis
AU - Dyakova, M. E.
AU - Alekseeva, N. P.
AU - Esmedlyaeva, D. S.
AU - Perova, T. L.
AU - Petrischev, N. N.
AU - Yablonsky, P. K.
N1 - Publisher Copyright: © 2017 New Terra Publishing House. All rights reserved. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Role of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: in infiltrate pulmonary tuberculosis patients it was within the limits of reference ranges, and in fibrous cavernous pulmonary tuberculosis patients it was significantly lower. Results of statistical analysis point out at the significant homogeneity (monofunctionality) of the set of rates, defining the level of NO metabolites in blood serum in infiltrate pulmonary tuberculosis, namely: impact of adenosine deaminase, levels of al-protease inhibitor, ceruleoplasmin and age. On the contrary in case of fibrous cavernous pulmonary tuberculosis the diverse (multi-functional) complexes were detected including clinical blood rates providing influence on the reduction of NO level in blood. Nitric oxide in the patients with both clinical forms of tuberculosis correlated with classical markers of system inflammatory response, thus nitric oxide can be regarded as an integral component of inflammatory response with potential evaluation of prognosis of specific lesions during follow-up of changes.
AB - Role of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: in infiltrate pulmonary tuberculosis patients it was within the limits of reference ranges, and in fibrous cavernous pulmonary tuberculosis patients it was significantly lower. Results of statistical analysis point out at the significant homogeneity (monofunctionality) of the set of rates, defining the level of NO metabolites in blood serum in infiltrate pulmonary tuberculosis, namely: impact of adenosine deaminase, levels of al-protease inhibitor, ceruleoplasmin and age. On the contrary in case of fibrous cavernous pulmonary tuberculosis the diverse (multi-functional) complexes were detected including clinical blood rates providing influence on the reduction of NO level in blood. Nitric oxide in the patients with both clinical forms of tuberculosis correlated with classical markers of system inflammatory response, thus nitric oxide can be regarded as an integral component of inflammatory response with potential evaluation of prognosis of specific lesions during follow-up of changes.
KW - Acute phase reactants
KW - General and endogenous nitrites
KW - Nitric oxide
KW - System inflammatory response
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85043794566&partnerID=8YFLogxK
U2 - 10.21292/2075-1230-2017-95-2-45-50
DO - 10.21292/2075-1230-2017-95-2-45-50
M3 - Article
AN - SCOPUS:85043794566
VL - 95
SP - 45
EP - 50
JO - ПРОБЛЕМЫ ТУБЕРКУЛЕЗА И БОЛЕЗНЕЙ ЛЕГКИХ
JF - ПРОБЛЕМЫ ТУБЕРКУЛЕЗА И БОЛЕЗНЕЙ ЛЕГКИХ
SN - 1728-2993
IS - 2
ER -
ID: 71600952