Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
New promising porphyrazine-based agents for optical theranostics of cancer. / Lermontova, S. A.; Grigor’ev, I. S.; Peskova, N. N.; Ladilina, E. Yu; Balalaeva, I. V.; Klapshina, L. G.; Boyarskii, V. P.
в: Russian Journal of General Chemistry, Том 87, № 3, 01.03.2017, стр. 479-484.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - New promising porphyrazine-based agents for optical theranostics of cancer
AU - Lermontova, S. A.
AU - Grigor’ev, I. S.
AU - Peskova, N. N.
AU - Ladilina, E. Yu
AU - Balalaeva, I. V.
AU - Klapshina, L. G.
AU - Boyarskii, V. P.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - New porphyrazine bases containing peripheral benzyloxyphenyl groups have been synthesized by the template method. The procedure includes condensation of aromatic aldehydes with malononitrile, transformation of arylmethylidenemalononitriles to arylethenetricarbonitriles, template assembly of porphyrazine macrocycle on bis(indenyl)ytterbium(II) complex, and removal of the central metal ion. Luminescence properties of the synthesized porphyrazines and their dependence on the viscosity of the medium were studied, and the light and dark toxicities of the porphyrazines have been estimated. The obtained results suggest the possibility of using these porphyrazines as optical theranostic agents of new generation.
AB - New porphyrazine bases containing peripheral benzyloxyphenyl groups have been synthesized by the template method. The procedure includes condensation of aromatic aldehydes with malononitrile, transformation of arylmethylidenemalononitriles to arylethenetricarbonitriles, template assembly of porphyrazine macrocycle on bis(indenyl)ytterbium(II) complex, and removal of the central metal ion. Luminescence properties of the synthesized porphyrazines and their dependence on the viscosity of the medium were studied, and the light and dark toxicities of the porphyrazines have been estimated. The obtained results suggest the possibility of using these porphyrazines as optical theranostic agents of new generation.
KW - optical intracellular viscosity probes
KW - optical theranostic agents
KW - photosensitizers
KW - porphyrazines
KW - template synthesis
KW - ytterbium complexes
UR - http://www.scopus.com/inward/record.url?scp=85018748747&partnerID=8YFLogxK
U2 - 10.1134/S1070363217030173
DO - 10.1134/S1070363217030173
M3 - Article
AN - SCOPUS:85018748747
VL - 87
SP - 479
EP - 484
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
SN - 1070-3632
IS - 3
ER -
ID: 13395342