Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
It is shown that the use of dimethylformamide dimethylacetal for the derivatization of analytes in gas chromatography/mass spectrometry cannot be restricted by the known conversion of carboxylic acids, phenols, and thiols into their methyl esters (ethers), as well as by the conversion of non-volatile amino acids (and C-amino compounds of other classes) into their dimethylaminomethylene derivatives. The application of this reagent to the derivatization of hydrazine derivatives and volatile carbonyl-containing analytes is considered. In the last case, the reaction proceeds selectively via CH2 and/or CH3 groups in the α-position to the carbonyl fragment. The principal predestination of the derivatization of such analytes is their characterization by differences of gas-chromatographic retention indices (ΔRI) of reaction products and initial substrates. The ranges of variation of such increments, ΔRI, appeared to be different for different subgroups of carbonyl compounds; this allowed us to determine their structures more precisely. The mass spectra of C-dimethylaminomethylene derivatives of some carbonyl compounds, preferably 2-substituted 1-methyl- and 1-aryl-3-(dimethylamino) prop-2-en-1-ones, revealed intense [M–17] peaks. The appearance of these signals can be explained by the migration of a hydrogen atom and the formation of [М–ОН]+ ions.
Переведенное название | Новые возможности использования диметилацеталя диметилформамида для дериватизации аналитов в хроматомасс-спектрометрии |
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Язык оригинала | английский |
Страницы (с-по) | 1341-1351 |
Число страниц | 11 |
Журнал | Journal of Analytical Chemistry |
Том | 71 |
Номер выпуска | 14 |
DOI | |
Состояние | Опубликовано - 1 дек 2016 |
ID: 9344314