Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
New lineage of microbial predators adds complexity to reconstructing the evolutionary origin of animals. / Tikhonenkov, Denis V. ; Mikhailov, Kirill V. ; Hehenberger, Elisabeth ; Karpov, Sergei A. ; Prokina, Kristina I. ; Esaulov, Anton S. ; Belyakova, Olga I. ; Mazeia, Yuri A. ; Mylnikov, Alexander P.; Aleoshin, Vladimir V.; Keeling, Patrick J.
в: Current Biology, Том 30, № 22, D-20-00927R2, 16.11.2020, стр. 4500-4509.e5.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - New lineage of microbial predators adds complexity to reconstructing the evolutionary origin of animals
AU - Tikhonenkov, Denis V.
AU - Mikhailov, Kirill V.
AU - Hehenberger, Elisabeth
AU - Karpov, Sergei A.
AU - Prokina, Kristina I.
AU - Esaulov, Anton S.
AU - Belyakova, Olga I.
AU - Mazeia, Yuri A.
AU - Mylnikov, Alexander P.
AU - Aleoshin, Vladimir V.
AU - Keeling, Patrick J.
N1 - Publisher Copyright: © 2020 Elsevier Inc.
PY - 2020/11/16
Y1 - 2020/11/16
N2 - The origin of animals is one of the most intensely studied evolutionary events, and ourunderstanding of this transition was greatly advanced by analyses of unicellular relatives ofanimals, which have shown many “animal-specific” genes actually arose in protistan ancestorslong before the emergence of animals [1-3]. These genes have complex distributions and theprotists have diverse lifestyles, so understanding their evolutionary significance requires both arobust phylogeny of animal relatives, and a detailed understanding of their biology [4, 5]. Butdiscoveries of new animal-related lineages are rare and historically biased to bacteriovores andparasites. Here, we characterize the morphology and transcriptome content of a new animalrelatedlineage, predatory flagellate Tunicaraptor unikontum. Tunicaraptor is an extremely small(3-5 μm) and morphologically simple cell superficially resembling some fungal zoospores, but itsurvives by preying on other eukaryotes possibly using a dedicated but transient “mouth”, whichis unique for unicellular opisthokonts. The Tunicaraptor transcriptome encodes a fullcomplement of flagellar genes, and the flagella-associated calcium channel which is onlycommon to predatory animal relatives and missing in microbial parasites and grazers.Tunicaraptor also encodes several major classes of animal cell adhesion molecules, as well astranscription factors and homologs of proteins involved in neurodevelopment that have not beenfound in other animal-related lineages. Phylogenomics including Tunicaraptor challenges theexisting framework used to reconstruct the evolution of “animal specific” genes, and emphasizesthat the diversity of animal-related lineages may be better understood only once the smaller,more inconspicuous animal-related lineages are better studied.
AB - The origin of animals is one of the most intensely studied evolutionary events, and ourunderstanding of this transition was greatly advanced by analyses of unicellular relatives ofanimals, which have shown many “animal-specific” genes actually arose in protistan ancestorslong before the emergence of animals [1-3]. These genes have complex distributions and theprotists have diverse lifestyles, so understanding their evolutionary significance requires both arobust phylogeny of animal relatives, and a detailed understanding of their biology [4, 5]. Butdiscoveries of new animal-related lineages are rare and historically biased to bacteriovores andparasites. Here, we characterize the morphology and transcriptome content of a new animalrelatedlineage, predatory flagellate Tunicaraptor unikontum. Tunicaraptor is an extremely small(3-5 μm) and morphologically simple cell superficially resembling some fungal zoospores, but itsurvives by preying on other eukaryotes possibly using a dedicated but transient “mouth”, whichis unique for unicellular opisthokonts. The Tunicaraptor transcriptome encodes a fullcomplement of flagellar genes, and the flagella-associated calcium channel which is onlycommon to predatory animal relatives and missing in microbial parasites and grazers.Tunicaraptor also encodes several major classes of animal cell adhesion molecules, as well astranscription factors and homologs of proteins involved in neurodevelopment that have not beenfound in other animal-related lineages. Phylogenomics including Tunicaraptor challenges theexisting framework used to reconstruct the evolution of “animal specific” genes, and emphasizesthat the diversity of animal-related lineages may be better understood only once the smaller,more inconspicuous animal-related lineages are better studied.
KW - Holozoa, phylogenomics, transcription factor, cell adhesion, Tunicaraptor, protists, origin of animals
KW - Holozoa, phylogenomics, transcription factor, cell adhesion, Tunicaraptor, protists, origin of animals
KW - transcription factor
KW - Holozoa
KW - Tunicaraptor
KW - origin of animals
KW - cell adhesion
KW - protists
KW - phylogenomics
UR - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3606769
UR - https://www.researchgate.net/publication/342119740_New_Lineage_of_Microbial_Predators_Adds_Complexity_to_Reconstructing_the_Evolutionary_Origin_of_Animals
UR - http://www.scopus.com/inward/record.url?scp=85092253831&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2020.08.061
DO - 10.1016/j.cub.2020.08.061
M3 - Article
VL - 30
SP - 4500-4509.e5
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 22
M1 - D-20-00927R2
ER -
ID: 61327563