TY - JOUR

T1 - Neuroprotective effect of hypobaric hypoxic postconditioning is accompanied by dna protection and lipid peroxidation changes in rat hippocampus

AU - Vetrovoy, Oleg

AU - Tulkova, Ekaterina

AU - Sarieva, Ksenia

AU - Kotryahova, Elena

AU - Zenko, Mikhail

AU - Rybnikova, Elena

N1 - Publisher Copyright: © 2016 Elsevier Ireland Ltd

PY - 2017/2/3

Y1 - 2017/2/3

N2 - The present study was performed to explore the effect of severe hypobaric hypoxia (180 Torr, 3 h) and severe hypoxia followed by hypoxic postconditioning (360 Torr, 2 h, 3 episodes) on DNA fragmentation and dynamics of lipid peroxidation products in rat hippocampus. The severe hypoxia induced intense DNA fragmentation in the hippocampus. A persistent decrease of thiobarbituric acid reactive substances in the hippocampus was also detected in response to severe hypoxia while the levels of Schiff bases did not significantly change. The postconditioning prevented severe hypoxia-induced DNA fragmentation, returned the levels of thiobarbituric acid reactive substances to the baseline and decreased the levels of Schiff bases. These findings indicate that the neuroprotective effect of hypoxic postconditioning on hippocampal neurons detected as suppression of hypoxia-induced DNA fragmentation is accompanied by the changes in lipid peroxidation processes.

AB - The present study was performed to explore the effect of severe hypobaric hypoxia (180 Torr, 3 h) and severe hypoxia followed by hypoxic postconditioning (360 Torr, 2 h, 3 episodes) on DNA fragmentation and dynamics of lipid peroxidation products in rat hippocampus. The severe hypoxia induced intense DNA fragmentation in the hippocampus. A persistent decrease of thiobarbituric acid reactive substances in the hippocampus was also detected in response to severe hypoxia while the levels of Schiff bases did not significantly change. The postconditioning prevented severe hypoxia-induced DNA fragmentation, returned the levels of thiobarbituric acid reactive substances to the baseline and decreased the levels of Schiff bases. These findings indicate that the neuroprotective effect of hypoxic postconditioning on hippocampal neurons detected as suppression of hypoxia-induced DNA fragmentation is accompanied by the changes in lipid peroxidation processes.

KW - DNA fragmentation

KW - Hippocampus

KW - Lipid peroxidation

KW - Mild hypobaric hypoxia postconditioning

KW - Neuroprotection.

KW - Severe hypobaric hypoxi a

UR - http://www.scopus.com/inward/record.url?scp=85007499715&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2016.12.054

DO - 10.1016/j.neulet.2016.12.054

M3 - Article

C2 - 28025115

AN - SCOPUS:85007499715

VL - 639

SP - 49

EP - 52

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -