TY - JOUR

T1 - Neuroimmunology

T2 - What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

AU - Ryabkova, Varvara A.

AU - Churilov, Leonid P

AU - Shoenfeld, Yehuda

N1 - Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/10/2

Y1 - 2019/10/2

N2 - Fibromyalgia is a disorder characterized by chronic widespread pain and non-pain symptoms, such as fatigue, dysautonomia, and cognitive and sleep disturbances. Its pathogenesis and treatment continue to be the subject of debate. We highlight the role of three mechanisms-autoimmunity, neuroinflammation, and small fiber neuropathy-in the pathogenesis of the disease. These mechanisms are shown to be closely interlinked (also on a molecular level), and the review considers the implementation of this relationship in the search for therapeutic options. We also pay attention to chronic fatigue syndrome, which overlaps with fibromyalgia, and propose a concept of "autoimmune hypothalamopathy" for its pathogenesis. Finally, we analyze the molecular mechanisms underlying the neuroinflammatory background in the development of adverse events following HPV vaccination and suggesting neuroinflammation, which could exacerbate the development of symptoms following HPV vaccination (though this is hotly debated), as a model for fibromyalgia pathogenesis.

AB - Fibromyalgia is a disorder characterized by chronic widespread pain and non-pain symptoms, such as fatigue, dysautonomia, and cognitive and sleep disturbances. Its pathogenesis and treatment continue to be the subject of debate. We highlight the role of three mechanisms-autoimmunity, neuroinflammation, and small fiber neuropathy-in the pathogenesis of the disease. These mechanisms are shown to be closely interlinked (also on a molecular level), and the review considers the implementation of this relationship in the search for therapeutic options. We also pay attention to chronic fatigue syndrome, which overlaps with fibromyalgia, and propose a concept of "autoimmune hypothalamopathy" for its pathogenesis. Finally, we analyze the molecular mechanisms underlying the neuroinflammatory background in the development of adverse events following HPV vaccination and suggesting neuroinflammation, which could exacerbate the development of symptoms following HPV vaccination (though this is hotly debated), as a model for fibromyalgia pathogenesis.

KW - fibromyalgia

KW - Autoimmunity

KW - autoantibodies

KW - Neuroinflammation

KW - Small fiber neuropathy

KW - Chronic fatigue syndrome

KW - HPV vaccine

KW - Autoantibodies

KW - Fibromyalgia

KW - ENCEPHALOMYELITIS

KW - DEPRESSION

KW - THYROID AUTOIMMUNITY

KW - CATHEPSIN-S

KW - HYPOTHALAMIC PARAVENTRICULAR NUCLEUS

KW - small fiber neuropathy

KW - CHOLINERGIC STIMULATION

KW - INHIBITION

KW - autoimmunity

KW - neuroinflammation

KW - HPV VACCINATION

KW - chronic fatigue syndrome

KW - DIAGNOSTIC-CRITERIA

KW - PITUITARY-ADRENAL AXIS

UR - http://www.scopus.com/inward/record.url?scp=85073655716&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/neuroimmunology-role-autoimmunity-neuroinflammation-small-fiber-neuropathy-fibromyalgia-chronic-fati

U2 - 10.3390/ijms20205164

DO - 10.3390/ijms20205164

M3 - статья

C2 - 31635218

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 20

M1 - 5164

ER -