In the article, recent data is reviewed, on neuro-humorall disbalance in chronic heart failure, including compensatory hyperactivation of sympathetic system, reninangiotensin-aldosterone system, endothelial system, endopeptides, and decrease of efficacy of the system of natriuretic peptides (atrial natriuretic peptide, brain natriuretic peptide, endothelial natriuretic peptide). In the review, it is shown that chronic heart failure as clinical syndrome is characterized by close interaction of hemodynamical dysfunction of myocardium and compensatory neuro-humoral mechanisms. All neuro-humoral mechanisms closely bound together acting in compensation of chronic heart failure progression, and many of them show compensatory role, as pathologic.