A total of 215 obese youths aged from 15 to 20 years were studied for lipid and carbohydrate metabolism, blood pressure and hormonal factors that regulated them (the performance of the thyroid gland and zona fasciculata of the adrenal cortex). The majority of the examinees revealed such atherosclerotic risk factors as arterial hypertension, diabetic pattern of carbohydrate metabolism disorders and type IIB, IV and IIA atherogenic dislipoproteinemia. In patients with juvenile dispituitarism there was dysfunction of hypophyseoadrenal systems which probably was important in pathogenesis of lipid and carbohydrate disbolism and arterial hypertension in them.