TY - JOUR

T1 - Nano-sized polymer and polymer-coated particles in electrokinetic separations

AU - Kartsova, L.A.

AU - Makeeva, D.V.

AU - Davankov, V.A.

PY - 2019/11

Y1 - 2019/11

N2 - Capillary electrophoresis (CE) is a rapidly developing method of efficient and selective separation of charged and uncharged compounds. Application of various modifiers of the background electrolyte (BGE) and capillary walls provide enhancement of selectivity and reproducibility of CE analyses. Nanoparticles (NPs) are the most promising modifiers, primarily due to their unique surface chemistry, formation of stable suspensions in BGEs, compatibilities with organic solvents and MS detection. Polymer NPs combine the advantages of nano-sized particles and the ease of dense functionalization. The combination of these properties can be also achieved by joint application of polymers with inorganic-based NPs. Here we review recent application examples of polymer NPs and discuss various synergetic examples of simultaneous use of polymers along with inorganic NPs for the separation of wide classes of compounds. We also consider approaches to capillary modification with NPs and types of “polymer-NPs” combinations for the coating and pseudo-stationary phase formation.

AB - Capillary electrophoresis (CE) is a rapidly developing method of efficient and selective separation of charged and uncharged compounds. Application of various modifiers of the background electrolyte (BGE) and capillary walls provide enhancement of selectivity and reproducibility of CE analyses. Nanoparticles (NPs) are the most promising modifiers, primarily due to their unique surface chemistry, formation of stable suspensions in BGEs, compatibilities with organic solvents and MS detection. Polymer NPs combine the advantages of nano-sized particles and the ease of dense functionalization. The combination of these properties can be also achieved by joint application of polymers with inorganic-based NPs. Here we review recent application examples of polymer NPs and discuss various synergetic examples of simultaneous use of polymers along with inorganic NPs for the separation of wide classes of compounds. We also consider approaches to capillary modification with NPs and types of “polymer-NPs” combinations for the coating and pseudo-stationary phase formation.

KW - polymer nanoparticles

KW - nanoparticles

KW - polymers

KW - capillary electrochromatography

KW - Micellar electrokinetic chromatography

KW - Capillary coatings

KW - Pseudo-stationary phase

U2 - DOI: 10.1016/j.trac.2019.115656

DO - DOI: 10.1016/j.trac.2019.115656

M3 - Article

VL - 120

JO - TrAC - Trends in Analytical Chemistry

JF - TrAC - Trends in Analytical Chemistry

SN - 0165-9936

M1 - 115656

ER -