TY - JOUR

T1 - Mutual influence of malignant cells and cellular microenvironment

T2 - prospects for manipulating tumour microenvironment with nanomaterials

AU - Malkova, Anna M.

AU - Ageev, Sergei V.

AU - Abdelhalim, Abdelsattar O.E.

AU - Molchanov, Oleg E.

AU - Maistrenko, Dmitrii N.

AU - Semenov, Konstantin N.

AU - Sharoyko, Vladimir V.

N1 - Publisher Copyright: © 2021, Universitatsklinikum Hamburg - Eppendorf. All rights reserved.

PY - 2021/12

Y1 - 2021/12

N2 - Development and progression of neoplasia occurs in par-allel with changes in the surrounding stroma. Cancer cells may functionally reshape their microenvironment by secreting various cytokines, chemokines and generation of acidic medium. These factors contribute to differentiation of immune cells into immunosuppressive phenotype, stimulate the synthesis of a number of amino acid me-tabolism enzymes, growth factors, adhesion molecules, which promote invasion, angiogenesis and metastasis, and also reduce efficiency of anticancer drugs and radia-tion therapy. To increase effectiveness of the chemother-apy, multitargeted carbon nanomaterials may be applied. In particular, nanomaterials based on modified graphene make it possible to create multicomponent therapeutic constructs, including macromolecules, polymers, and effector agents. Initial experiments with unmodified graphenes demonstrated their toxicity associated with their accumulation in parenchymal organs and initiation of inflammatory processes. In the past few years, a series of works has been published in which the possibility of reducing the toxicity of graphene oxide through function-alisation has been demonstrated. This review summaris-es the experimental data on the creation of covalent and non-covalent conjugates based on graphene oxide and demonstrates their in vitro efficacy on various tumour cell lines. Separately, there are few data on the effect of nanomaterials based on graphene oxide on the tumour microenvironment.

AB - Development and progression of neoplasia occurs in par-allel with changes in the surrounding stroma. Cancer cells may functionally reshape their microenvironment by secreting various cytokines, chemokines and generation of acidic medium. These factors contribute to differentiation of immune cells into immunosuppressive phenotype, stimulate the synthesis of a number of amino acid me-tabolism enzymes, growth factors, adhesion molecules, which promote invasion, angiogenesis and metastasis, and also reduce efficiency of anticancer drugs and radia-tion therapy. To increase effectiveness of the chemother-apy, multitargeted carbon nanomaterials may be applied. In particular, nanomaterials based on modified graphene make it possible to create multicomponent therapeutic constructs, including macromolecules, polymers, and effector agents. Initial experiments with unmodified graphenes demonstrated their toxicity associated with their accumulation in parenchymal organs and initiation of inflammatory processes. In the past few years, a series of works has been published in which the possibility of reducing the toxicity of graphene oxide through function-alisation has been demonstrated. This review summaris-es the experimental data on the creation of covalent and non-covalent conjugates based on graphene oxide and demonstrates their in vitro efficacy on various tumour cell lines. Separately, there are few data on the effect of nanomaterials based on graphene oxide on the tumour microenvironment.

KW - acidosis

KW - carbon nanomaterials

KW - cytokines

KW - immune system

KW - microenvironment

KW - progression

KW - Tumour

UR - http://www.scopus.com/inward/record.url?scp=85126923083&partnerID=8YFLogxK

U2 - 10.18620/ctt-1866-8836-2021-10-3-4-8-18

DO - 10.18620/ctt-1866-8836-2021-10-3-4-8-18

M3 - Review article

AN - SCOPUS:85126923083

VL - 10

SP - 8

EP - 18

JO - Cellular Therapy and Transplantation

JF - Cellular Therapy and Transplantation

SN - 1867-416X

IS - 3-4

ER -