The next-generation Event Horizon Telescope (ngEHT) will provide us with the best opportunity to investigate supermassive black holes (SMBHs) at the highest possible resolution and sensitivity. With respect to the existing Event Horizon Telescope (EHT) array, the ngEHT will provide increased sensitivity and uv-coverage (with the addition of new stations), wider frequency coverage (from 86 GHz to 345 GHz and higher), finer resolution (<15 micro-arcseconds), and better monitoring capabilities. The ngEHT will offer a unique opportunity to deeply investigate the physics around SMBHs, such as the disk-jet connection, the mechanisms responsible for high-energy photon and neutrino events, and the role of magnetic fields in shaping relativistic jets, as well as the nature of binary SMBH systems. In this white paper we describe some ngEHT science cases in the context of multi-wavelength studies and synergies.