Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Конечная издательская версия
Конечная издательская версия
Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci for published summary statistics of problematic alcohol use, problematic tobacco use, cannabis use disorder, and opioid use disorder in a sample of 1,025,550 individuals of European descent and 92,630 individuals of African descent. Nineteen independent SNPs were genome-wide significant ( P < 5e-8) for the general addiction risk factor ( addiction-rf), which showed high polygenicity. Across ancestries, PDE4B was significant (among other genes), suggesting dopamine regulation as a cross-substance vulnerability. An addiction-rf polygenic risk score was associated with substance use disorders, psychopathologies, somatic conditions, and environments associated with the onset of addictions. Substance-specific loci (9 for alcohol, 32 for tobacco, 5 for cannabis, 1 for opioids) included metabolic and receptor genes. These findings provide insight into genetic risk loci for substance use disorders that could be leveraged as treatment targets.
Язык оригинала | английский |
---|---|
Страницы (с-по) | 210–223 |
Число страниц | 14 |
Журнал | Nature mental health |
Том | 1 |
Номер выпуска | 3 |
DOI | |
Состояние | Опубликовано - 22 мар 2023 |
ID: 107029902