Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. / Furlan, Alessandro; Dyachuk, Vyacheslav; Kastriti, Maria Eleni; Calvo-Enrique, Laura; Abdo, Hind; Hadjab, Saida; Chontorotzea, Tatiana; Akkuratova, Natalia; Usoskin, Dmitry; Kamenev, Dmitry; Petersen, Julian; Sunadome, Kazunori; Memic, Fatima; Marklund, Ulrika; Fried, Kaj; Topilko, Piotr; Lallemend, Francois; Kharchenko, Peter V.; Ernfors, Patrik; Adameyko, Igor.
в: Science, Том 357, № 6346, 46, 07.07.2017.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
AU - Furlan, Alessandro
AU - Dyachuk, Vyacheslav
AU - Kastriti, Maria Eleni
AU - Calvo-Enrique, Laura
AU - Abdo, Hind
AU - Hadjab, Saida
AU - Chontorotzea, Tatiana
AU - Akkuratova, Natalia
AU - Usoskin, Dmitry
AU - Kamenev, Dmitry
AU - Petersen, Julian
AU - Sunadome, Kazunori
AU - Memic, Fatima
AU - Marklund, Ulrika
AU - Fried, Kaj
AU - Topilko, Piotr
AU - Lallemend, Francois
AU - Kharchenko, Peter V.
AU - Ernfors, Patrik
AU - Adameyko, Igor
PY - 2017/7/7
Y1 - 2017/7/7
N2 - Adrenaline is a fundamental circulating hormone for bodily responses to internal and external stressors. Chromaffin cells of the adrenal medulla (AM) represent the main neuroendocrine adrenergic component and are believed to differentiate from neural crest cells. We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells, termed Schwann cell precursors (SCPs). SCPs migrate along the visceral motor nerve to the vicinity of the forming adrenal gland, where they detach from the nerve and form postsynaptic neuroendocrine chromaffin cells. An intricate molecular logic drives two sequential phases of gene expression, one unique for a distinct transient cellular state and another for cell type specification. Subsequently, these programs down-regulate SCP-gene and up-regulate chromaffin cell–gene networks. The AM forms through limited cell expansion and requires the recruitment of numerous SCPs. Thus, peripheral nerves serve as a stem cell niche for neuroendocrine system development.
AB - Adrenaline is a fundamental circulating hormone for bodily responses to internal and external stressors. Chromaffin cells of the adrenal medulla (AM) represent the main neuroendocrine adrenergic component and are believed to differentiate from neural crest cells. We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells, termed Schwann cell precursors (SCPs). SCPs migrate along the visceral motor nerve to the vicinity of the forming adrenal gland, where they detach from the nerve and form postsynaptic neuroendocrine chromaffin cells. An intricate molecular logic drives two sequential phases of gene expression, one unique for a distinct transient cellular state and another for cell type specification. Subsequently, these programs down-regulate SCP-gene and up-regulate chromaffin cell–gene networks. The AM forms through limited cell expansion and requires the recruitment of numerous SCPs. Thus, peripheral nerves serve as a stem cell niche for neuroendocrine system development.
UR - http://www.scopus.com/inward/record.url?scp=85024098378&partnerID=8YFLogxK
U2 - 10.1126/science.aal3753
DO - 10.1126/science.aal3753
M3 - Article
C2 - 28684471
AN - SCOPUS:85024098378
VL - 357
JO - Science
JF - Science
SN - 0036-8075
IS - 6346
M1 - 46
ER -
ID: 48922564