Multiple pregnancy care based only on knowledge of fetal nuber does not satisfy clinical practice any more. Appropriate clinical use of data, obtained via skilled and timely ultrasound has been proven to be a great value for reduction of typical complicaion rate in multiple pragnancy for both fetus and mother. Ultrasonography plays a key role when intrauterine interventions during pregnancy are required. It can be succesfully used for both precise prenatal diagnosis of numerous chromosomal and congenital diseases and antenatal treatment of multiple pregnancy-specific complications.