TY - JOUR

T1 - Multicomponent DNAzyme Nanomachines: Structure, Applications, and Prospects

AU - Nedorezova, Daria D.

AU - Rubel, Maria S.

AU - Rubel, Aleksandr A.

N1 - Nedorezova D.D., Rubel M.S., Rubel A.A. Multicomponent DNAzyme Nanomachines: Structure, Applications, and Prospects. Biochemistry Moscow 89 (Suppl 1), S249–S261 (2024). https://doi.org/10.1134/S0006297924140141

PY - 2024/3/8

Y1 - 2024/3/8

N2 - Abstract: Nucleic acids (NAs) are important components of living organisms responsible for the storage and transmission of hereditary information. They form complex structures that can self-assemble and bind to various biological molecules. DNAzymes are NAs capable of performing simple chemical reactions, which makes them potentially useful elements for creating DNA nanomachines with required functions. This review focuses on multicomponent DNA-based nanomachines, in particular on DNAzymes as their main functional elements, as well as on the structure of DNAzyme nanomachines and their application in the diagnostics and treatment of diseases. The article also discusses the advantages and disadvantages of DNAzyme-based nanomachines and prospects for their future applications. The review provides information about new technologies and the possibilities of using NAs in medicine.

AB - Abstract: Nucleic acids (NAs) are important components of living organisms responsible for the storage and transmission of hereditary information. They form complex structures that can self-assemble and bind to various biological molecules. DNAzymes are NAs capable of performing simple chemical reactions, which makes them potentially useful elements for creating DNA nanomachines with required functions. This review focuses on multicomponent DNA-based nanomachines, in particular on DNAzymes as their main functional elements, as well as on the structure of DNAzyme nanomachines and their application in the diagnostics and treatment of diseases. The article also discusses the advantages and disadvantages of DNAzyme-based nanomachines and prospects for their future applications. The review provides information about new technologies and the possibilities of using NAs in medicine.

KW - ДНК-наномашины

KW - ДНКзим

KW - детекция нуклеиновых кислот

KW - тераностика

KW - таргетная терапия рака

KW - DNA nanomachines

KW - DNAzyme 10-23

KW - DNAzymes

KW - nucleic acid diagnostics

KW - targeted cancer therapy

KW - theranostics

UR - https://link.springer.com/article/10.1134/S0006297924140141

UR - https://www.mendeley.com/catalogue/bf8073e5-cb66-32ce-b008-9dda0e2f5c5f/

U2 - 10.1134/s0006297924140141

DO - 10.1134/s0006297924140141

M3 - Review article

VL - 89

SP - S249-S261

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - Suppl 1

ER -