The Miridae, or plant bugs, is one of the largest insect families, comprising about 25% of all true bug species (order Heteroptera). The tribe Halticini from the mirid subfamily Orthotylinae includes 26 extremely diverse genera and is usually considered a thoroughly studied and well-defined group. However, only a morphology-based phylogeny has been presented for the tribe, its monophyly has not been tested and its largest groups lacked synapomorphies. In the present study we combined morphological (79 characters) and molecular (12S, 16S, 18S, 28S, COI, cytb) data for 123 taxa, including 60 taxa from other Orthotylinae tribes and four other mirid subfamilies (Bryocorinae, Cylapinae, Deraeocorinae, Mirinae, Phylinae). The results of the analyses using the methods of Bayesian inference and maximum likelihood (IQTree, RAxML) showed non-monophyly of the subfamily Orthotylinae, tribe Halticini and several genera, leading to reconsideration of the plant bug taxonomy.