Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › Рецензирование
Non-invasive optical techniques on the basis of quenching of phosphorescence by molecular oxygen represent a powerful tool to perform mapping of oxygen content in biological systems. The development of phosphorescent oxygensensitive probes suitable for biological applications, especially in vivo, remains a challenging task. In this paper we applied for biological investigations one novel and one previously published Ir(III)-based complexes. This complexes demonstrate low cytotoxicity at the concentrations ≤70 μM and good uptake by cultured cancer cells. Both compounds were primarily located within the cytoplasm. Using TCSPC-based phosphorescence lifetime macro-imaging in vivo, we found that IR-2 complex shows detectable phosphorescence in tumor tissue in mice upon local injection. These results illustrate the high potential of organometallic complexes under study for mapping of oxygen level in cells and tissues.
Язык оригинала | английский |
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Название основной публикации | Optical Biopsy XVIII |
Подзаголовок основной публикации | Toward Real-Time Spectroscopic Imaging and Diagnosis |
Редакторы | Robert R. Alfano, Stavros G. Demos, Angela B. Seddon |
Издатель | SPIE |
Число страниц | 8 |
ISBN (электронное издание) | 9781510632318 |
DOI | |
Состояние | Опубликовано - 21 фев 2020 |
Событие | Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020 - San Francisco, Соединенные Штаты Америки Продолжительность: 2 фев 2020 → 5 фев 2020 |
Название | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
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Том | 11234 |
ISSN (печатное издание) | 1605-7422 |
конференция | Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020 |
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Страна/Tерритория | Соединенные Штаты Америки |
Город | San Francisco |
Период | 2/02/20 → 5/02/20 |
ID: 53243493