TY - JOUR

T1 - Molecular dynamics investigation of nitric oxide (II) interaction with a model biological membrane

AU - Mamonov, A. A.

AU - Stefanov, V. E.

AU - Shchegolev, B. F.

N1 - Funding Information: ACKNOWLEDGMENTS The work is supported by the Ministry of Education and Science (RNP project no. 2.1.1.4139), St.-Petersburg Scientific Center (Complex Interdisciplinary Projects), and St.-Petersburg State University (Program Nanobiology).

PY - 2009

Y1 - 2009

N2 - Nitric oxide (II) diffusion through a model two-component (phosphatidylcholine and phosphatidylethanolamine molecules) biological membrane is investigated using the molecular dynamics method. It is shown that NO molecules are rotating in the process of diffusion into the phospholipid bilayer. The calculated diffusion coefficient D [NO] = 0.35 (±0.23) × 10-5 (cm2/s) is in a good agreement with literature data. This testifies that free diffusion of NO molecules may be a plausible mechanism of the NO permeation through the membranes.

AB - Nitric oxide (II) diffusion through a model two-component (phosphatidylcholine and phosphatidylethanolamine molecules) biological membrane is investigated using the molecular dynamics method. It is shown that NO molecules are rotating in the process of diffusion into the phospholipid bilayer. The calculated diffusion coefficient D [NO] = 0.35 (±0.23) × 10-5 (cm2/s) is in a good agreement with literature data. This testifies that free diffusion of NO molecules may be a plausible mechanism of the NO permeation through the membranes.

KW - Biological membranes

KW - Diffusion

KW - Molecular dynamics

KW - Nitric oxide (II)

UR - http://www.scopus.com/inward/record.url?scp=67650290007&partnerID=8YFLogxK

U2 - 10.1134/S1990747809020172

DO - 10.1134/S1990747809020172

M3 - Article

AN - SCOPUS:67650290007

VL - 3

SP - 231

EP - 238

JO - Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

JF - Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

SN - 1990-7478

IS - 2

ER -