TY - JOUR

T1 - Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter

AU - Sotnikova, Tatyana D.

AU - Beaulieu, Jean Martin

AU - Gainetdinov, Raul R.

AU - Caron, Marc G.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - The plasma membrane dopamine transporter (DAT) tightly regulates the extracellular concentrations of dopamine (DA) by re-capturing released neurotransmitter back into the presynaptic neuronal terminals and/or neighboring DA projections thereby providing an effective way to regulate synaptic and extrasynaptic DA levels. This transporter is a primary target of many potent psychotropic drugs and neurotoxins, such as cocaine, amphetamines and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this review we summarize recent advances in understanding the structure, regulation, and functional roles of DAT in normal DA physiology and pathological conditions, such as attention deficit hyperactivity disorder (ADHD) and neurodegenerative processes, as well as their contribution to the pharmacology of psychostimulant drugs. Significant new insights on these issues have been gained using mice with genetic deletion of DAT.

AB - The plasma membrane dopamine transporter (DAT) tightly regulates the extracellular concentrations of dopamine (DA) by re-capturing released neurotransmitter back into the presynaptic neuronal terminals and/or neighboring DA projections thereby providing an effective way to regulate synaptic and extrasynaptic DA levels. This transporter is a primary target of many potent psychotropic drugs and neurotoxins, such as cocaine, amphetamines and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this review we summarize recent advances in understanding the structure, regulation, and functional roles of DAT in normal DA physiology and pathological conditions, such as attention deficit hyperactivity disorder (ADHD) and neurodegenerative processes, as well as their contribution to the pharmacology of psychostimulant drugs. Significant new insights on these issues have been gained using mice with genetic deletion of DAT.

KW - ADHD

KW - Dopamine transporter

KW - Knockout mice

KW - Neurodegeneration

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=33646698660&partnerID=8YFLogxK

U2 - 10.2174/187152706784111579

DO - 10.2174/187152706784111579

M3 - Article

C2 - 16613553

AN - SCOPUS:33646698660

VL - 5

SP - 45

EP - 56

JO - CNS and Neurological Disorders - Drug Targets

JF - CNS and Neurological Disorders - Drug Targets

SN - 1871-5273

IS - 1

ER -