Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Molecular basis of the development of Parkinson's disease. / Absalyamova, Margarita; Traktirov, Dmitrii; Burdinskaya, Viktoria; Artemova, Valeria; Muruzheva, Zamira; Karpenko, Marina.
в: Neuroscience, Том 565, 07.12.2024, стр. 292-300.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Molecular basis of the development of Parkinson's disease
AU - Absalyamova, Margarita
AU - Traktirov, Dmitrii
AU - Burdinskaya, Viktoria
AU - Artemova, Valeria
AU - Muruzheva, Zamira
AU - Karpenko, Marina
N1 - Copyright © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.
PY - 2024/12/7
Y1 - 2024/12/7
N2 - Parkinson's disease is one of the most prevalent neurodegenerative motor disorders worldwide with postural instability, bradykinesia, resting tremor and rigidity being the most common symptoms of the disease. Despite the fact that the molecular mechanisms of Parkinson's disease pathogenesis have already been well described, there is still no coherent picture of the etiopathogenesis of this disease. According to modern concepts, neurodegeneration is induced mainly by oxidative stress, neuroinflammation, dysregulation of cerebral proteostasis, apoptotic dysregulation, and impaired autophagy. This review describes how various factors contribute to neurodegeneration in Parkinson's disease. Understanding the factors affecting fundamental cellular processes and responsible for disease progression may help develop therapeutic strategies to improve the quality of life of patients suffering from the disease. The review also discusses the role of calpains in the development of Parkinson's disease. It is known that α-synuclein is a substrate of calcium-dependent proteases of the calpain family. Truncated forms of α-synuclein are not only involved in the process of formation of the aggregates, but also increase their toxicity.
AB - Parkinson's disease is one of the most prevalent neurodegenerative motor disorders worldwide with postural instability, bradykinesia, resting tremor and rigidity being the most common symptoms of the disease. Despite the fact that the molecular mechanisms of Parkinson's disease pathogenesis have already been well described, there is still no coherent picture of the etiopathogenesis of this disease. According to modern concepts, neurodegeneration is induced mainly by oxidative stress, neuroinflammation, dysregulation of cerebral proteostasis, apoptotic dysregulation, and impaired autophagy. This review describes how various factors contribute to neurodegeneration in Parkinson's disease. Understanding the factors affecting fundamental cellular processes and responsible for disease progression may help develop therapeutic strategies to improve the quality of life of patients suffering from the disease. The review also discusses the role of calpains in the development of Parkinson's disease. It is known that α-synuclein is a substrate of calcium-dependent proteases of the calpain family. Truncated forms of α-synuclein are not only involved in the process of formation of the aggregates, but also increase their toxicity.
KW - Humans
KW - Parkinson Disease/metabolism
KW - Animals
KW - Calpain/metabolism
KW - alpha-Synuclein/metabolism
KW - Oxidative Stress/physiology
KW - Dopaminergic neurons
KW - Calpains
KW - Molecular pathways
KW - Alpha synuclein
KW - Parkinson's disease
UR - https://www.mendeley.com/catalogue/4345a49a-437a-3d5d-a969-5867c7a4fd74/
U2 - 10.1016/j.neuroscience.2024.12.009
DO - 10.1016/j.neuroscience.2024.12.009
M3 - Review article
C2 - 39653246
VL - 565
SP - 292
EP - 300
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
ER -
ID: 140458134