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Modulation of NK Cell Properties by ESKAPE Group Bacteria. / Гребенкина, П.В.; Юхина, Варвара Алексеевна; Тыщук, Елизавета Владимировна; Гулина, Анастасия Максимовна; Денисова, Елизавета Алексеевна; Korobova, Zoia R.; Орлов, Сергей Николаевич; Тотолян, Арег Артемович; Краева, Людмила Александровна; Соколов, Д. И.

в: International Journal of Molecular Sciences, Том 26, № 17, 8449, 30.08.2025.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Гребенкина, ПВ, Юхина, ВА, Тыщук, ЕВ, Гулина, АМ, Денисова, ЕА, Korobova, ZR, Орлов, СН, Тотолян, АА, Краева, ЛА & Соколов, ДИ 2025, 'Modulation of NK Cell Properties by ESKAPE Group Bacteria', International Journal of Molecular Sciences, Том. 26, № 17, 8449. https://doi.org/10.3390/ijms26178449

APA

Гребенкина, П. В., Юхина, В. А., Тыщук, Е. В., Гулина, А. М., Денисова, Е. А., Korobova, Z. R., Орлов, С. Н., Тотолян, А. А., Краева, Л. А., & Соколов, Д. И. (2025). Modulation of NK Cell Properties by ESKAPE Group Bacteria. International Journal of Molecular Sciences, 26(17), [8449]. https://doi.org/10.3390/ijms26178449

Vancouver

Гребенкина ПВ, Юхина ВА, Тыщук ЕВ, Гулина АМ, Денисова ЕА, Korobova ZR и пр. Modulation of NK Cell Properties by ESKAPE Group Bacteria. International Journal of Molecular Sciences. 2025 Авг. 30;26(17). 8449. https://doi.org/10.3390/ijms26178449

Author

Гребенкина, П.В. ; Юхина, Варвара Алексеевна ; Тыщук, Елизавета Владимировна ; Гулина, Анастасия Максимовна ; Денисова, Елизавета Алексеевна ; Korobova, Zoia R. ; Орлов, Сергей Николаевич ; Тотолян, Арег Артемович ; Краева, Людмила Александровна ; Соколов, Д. И. / Modulation of NK Cell Properties by ESKAPE Group Bacteria. в: International Journal of Molecular Sciences. 2025 ; Том 26, № 17.

BibTeX

@article{9d72e5402b2442a586acd9df68abf8b9,
title = "Modulation of NK Cell Properties by ESKAPE Group Bacteria",
abstract = "Functions of natural killer cells (NK cells) can be modulated by environmental stimuli. However, the role of bacterial components in this modulation remains an area of ongoing research. This study investigates how bacterial supernatants influence NK cell function-including cytotoxicity, phenotype, and cytokine and mRNA production-following co-culture. These parameters were measured by flow cytometry and RT-PCR. We found that NK cells express TLR2 and TLR5, and that exposure to supernatants from ESKAPE group bacteria modified their cytotoxicity against JEG-3 and K-562 cell lines and their NKG2A and IL-10 mRNA levels. Our findings indicate that bacteria can modify NK cell features and their interactions with other cells in the microenvironment. ",
keywords = "Killer Cells, Natural/immunology, Humans, Toll-Like Receptor 2/metabolism, Coculture Techniques, Interleukin-10/genetics, Cytotoxicity, Immunologic, Cytokines/metabolism, Bacteria/immunology, Cell Line, Tumor, maternal-fetal interface, ESKAPE group, natural killer (NK) cells, cancer, cytotoxicity",
author = "П.В. Гребенкина and Юхина, {Варвара Алексеевна} and Тыщук, {Елизавета Владимировна} and Гулина, {Анастасия Максимовна} and Денисова, {Елизавета Алексеевна} and Korobova, {Zoia R.} and Орлов, {Сергей Николаевич} and Тотолян, {Арег Артемович} and Краева, {Людмила Александровна} and Соколов, {Д. И.}",
year = "2025",
month = aug,
day = "30",
doi = "10.3390/ijms26178449",
language = "English",
volume = "26",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI AG",
number = "17",

}

RIS

TY - JOUR

T1 - Modulation of NK Cell Properties by ESKAPE Group Bacteria

AU - Гребенкина, П.В.

AU - Юхина, Варвара Алексеевна

AU - Тыщук, Елизавета Владимировна

AU - Гулина, Анастасия Максимовна

AU - Денисова, Елизавета Алексеевна

AU - Korobova, Zoia R.

AU - Орлов, Сергей Николаевич

AU - Тотолян, Арег Артемович

AU - Краева, Людмила Александровна

AU - Соколов, Д. И.

PY - 2025/8/30

Y1 - 2025/8/30

N2 - Functions of natural killer cells (NK cells) can be modulated by environmental stimuli. However, the role of bacterial components in this modulation remains an area of ongoing research. This study investigates how bacterial supernatants influence NK cell function-including cytotoxicity, phenotype, and cytokine and mRNA production-following co-culture. These parameters were measured by flow cytometry and RT-PCR. We found that NK cells express TLR2 and TLR5, and that exposure to supernatants from ESKAPE group bacteria modified their cytotoxicity against JEG-3 and K-562 cell lines and their NKG2A and IL-10 mRNA levels. Our findings indicate that bacteria can modify NK cell features and their interactions with other cells in the microenvironment.

AB - Functions of natural killer cells (NK cells) can be modulated by environmental stimuli. However, the role of bacterial components in this modulation remains an area of ongoing research. This study investigates how bacterial supernatants influence NK cell function-including cytotoxicity, phenotype, and cytokine and mRNA production-following co-culture. These parameters were measured by flow cytometry and RT-PCR. We found that NK cells express TLR2 and TLR5, and that exposure to supernatants from ESKAPE group bacteria modified their cytotoxicity against JEG-3 and K-562 cell lines and their NKG2A and IL-10 mRNA levels. Our findings indicate that bacteria can modify NK cell features and their interactions with other cells in the microenvironment.

KW - Killer Cells, Natural/immunology

KW - Humans

KW - Toll-Like Receptor 2/metabolism

KW - Coculture Techniques

KW - Interleukin-10/genetics

KW - Cytotoxicity, Immunologic

KW - Cytokines/metabolism

KW - Bacteria/immunology

KW - Cell Line, Tumor

KW - maternal-fetal interface

KW - ESKAPE group

KW - natural killer (NK) cells

KW - cancer

KW - cytotoxicity

UR - https://www.mdpi.com/1422-0067/26/17/8449

UR - https://www.mendeley.com/catalogue/808171dc-ca77-3c81-872b-70ae421328f1/

U2 - 10.3390/ijms26178449

DO - 10.3390/ijms26178449

M3 - Article

C2 - 40943371

VL - 26

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 17

M1 - 8449

ER -

ID: 140416653