Результаты исследований: Научные публикации в периодических изданиях › Обзор литературы › Рецензирование
Modifiers of membrane dipole potentials as tools for investigating ion channel formation and functioning. / Ostroumova, Olga S.; Efimova, Svetlana S.; Malev, Valery V.
в: International Review of Cell and Molecular Biology, Том 315, 2015, стр. 245-297.Результаты исследований: Научные публикации в периодических изданиях › Обзор литературы › Рецензирование
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TY - JOUR
T1 - Modifiers of membrane dipole potentials as tools for investigating ion channel formation and functioning
AU - Ostroumova, Olga S.
AU - Efimova, Svetlana S.
AU - Malev, Valery V.
PY - 2015
Y1 - 2015
N2 - Electrostatic fields generated on and within biological membranes play a fundamental role in key processes in cell functions. The role of the membrane dipole potential is of particular interest because of its powerful impact on membrane permeability and lipid-protein interactions, including protein insertion, oligomerization, and function. The membrane dipole potential is defined by the orientation of electric dipoles of lipid headgroups, fatty acid carbonyl groups, and membrane-adsorbed water. As a result, the membrane interior is several hundred millivolts more positive than the external aqueous phase. This potential decrease depends on the lipid, and especially sterol, composition of the membrane. The adsorption of certain electroneutral molecules known as dipole modifiers may also lead to significant changes in the magnitude of the potential decrease. These agents are widely used to study the effects of the dipole potential on membrane transport. This review presents a critical analysis of a variety of da
AB - Electrostatic fields generated on and within biological membranes play a fundamental role in key processes in cell functions. The role of the membrane dipole potential is of particular interest because of its powerful impact on membrane permeability and lipid-protein interactions, including protein insertion, oligomerization, and function. The membrane dipole potential is defined by the orientation of electric dipoles of lipid headgroups, fatty acid carbonyl groups, and membrane-adsorbed water. As a result, the membrane interior is several hundred millivolts more positive than the external aqueous phase. This potential decrease depends on the lipid, and especially sterol, composition of the membrane. The adsorption of certain electroneutral molecules known as dipole modifiers may also lead to significant changes in the magnitude of the potential decrease. These agents are widely used to study the effects of the dipole potential on membrane transport. This review presents a critical analysis of a variety of da
M3 - Literature review
VL - 315
SP - 245
EP - 297
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
SN - 1937-6448
ER -
ID: 5764870