Copolymers glycidyl methacrylate-ethylene dimethacrylate which proved to be well suited for size exclusion chromatographic separations in water solutions were provided with hydrophobic alkyl chains containing 4 or 8 carbon atoms or with hydrogen sulfonate groups by simple chemical modifications. Separations of model protein mixtures document the suitability of these sorbents for hydrophobic interaction and ion-exchange chromatography and suggest ways for fine adjustment of the chromatographic conditions assuring the optimal result.