Standard

Modification of contact lenses via metal-organic frameworks for glaucoma treatment. / Yaremenko, A.V.; Melikov, R.O.; Pechnikova, N.A.; Belyaev, I.B.; Ringaci, A.; Yaremenko, T.V.; Mirkasymov, A.B.; Tamgin, A.A.; Rodionov, V.I.; Dolotova, S.M.; Plisko, G.A.; Semivelichenko, E.D.; Rogova, A.S.; Muslimov, A.R.; Ivkina, A.S.; Ivkin, D.Y.; Erichev, V.P.; Deyev, S.M.; Avetisov, S.E.; Li, Y.; Liu, H.-J.; Zelepukin, I.V.

в: Aggregate, Том 5, № 5, 2024.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Yaremenko, AV, Melikov, RO, Pechnikova, NA, Belyaev, IB, Ringaci, A, Yaremenko, TV, Mirkasymov, AB, Tamgin, AA, Rodionov, VI, Dolotova, SM, Plisko, GA, Semivelichenko, ED, Rogova, AS, Muslimov, AR, Ivkina, AS, Ivkin, DY, Erichev, VP, Deyev, SM, Avetisov, SE, Li, Y, Liu, H-J & Zelepukin, IV 2024, 'Modification of contact lenses via metal-organic frameworks for glaucoma treatment', Aggregate, Том. 5, № 5. https://doi.org/10.1002/agt2.586

APA

Yaremenko, A. V., Melikov, R. O., Pechnikova, N. A., Belyaev, I. B., Ringaci, A., Yaremenko, T. V., Mirkasymov, A. B., Tamgin, A. A., Rodionov, V. I., Dolotova, S. M., Plisko, G. A., Semivelichenko, E. D., Rogova, A. S., Muslimov, A. R., Ivkina, A. S., Ivkin, D. Y., Erichev, V. P., Deyev, S. M., Avetisov, S. E., ... Zelepukin, I. V. (2024). Modification of contact lenses via metal-organic frameworks for glaucoma treatment. Aggregate, 5(5). https://doi.org/10.1002/agt2.586

Vancouver

Yaremenko AV, Melikov RO, Pechnikova NA, Belyaev IB, Ringaci A, Yaremenko TV и пр. Modification of contact lenses via metal-organic frameworks for glaucoma treatment. Aggregate. 2024;5(5). https://doi.org/10.1002/agt2.586

Author

Yaremenko, A.V. ; Melikov, R.O. ; Pechnikova, N.A. ; Belyaev, I.B. ; Ringaci, A. ; Yaremenko, T.V. ; Mirkasymov, A.B. ; Tamgin, A.A. ; Rodionov, V.I. ; Dolotova, S.M. ; Plisko, G.A. ; Semivelichenko, E.D. ; Rogova, A.S. ; Muslimov, A.R. ; Ivkina, A.S. ; Ivkin, D.Y. ; Erichev, V.P. ; Deyev, S.M. ; Avetisov, S.E. ; Li, Y. ; Liu, H.-J. ; Zelepukin, I.V. / Modification of contact lenses via metal-organic frameworks for glaucoma treatment. в: Aggregate. 2024 ; Том 5, № 5.

BibTeX

@article{8dd19967214b40fbbce07eb5393a6bd0,
title = "Modification of contact lenses via metal-organic frameworks for glaucoma treatment",
abstract = "The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure. Here, human contact lenses are modified with highly porous metal-organic frameworks with sustained release of brimonidine for prolonged glaucoma treatment. Various metal-organic frameworks were screened for their attachment to lenses, loading with brimonidine, and drug-release properties. Optimized therapeutic ocular lenses conjugated with MIL-101(Cr) frameworks maintain optical transparency and power. Coating of lenses with MIL-101(Cr) nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the cornea. The hybrid lenses provided a 4.5-fold better decrease in eye pressure, compared by area under the curve (AUC) value to a commercially available brimonidine tartrate solution. Therapeutic lenses did not induce any notable eye irritation or corneal damage in vivo. The newly developed hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases. {\textcopyright} 2024 Elsevier B.V., All rights reserved.",
keywords = "brimonidine, contact lenses, drug delivery, glaucoma, intraocular pressure, metal-organic frameworks, nanoparticles, Contact lenses, Disease control, Metal nanoparticles, Metal-Organic Frameworks, Ophthalmology, Targeted drug delivery, Australia, Brimonidine, Drug release properties, Glaucoma, Hybrid lens, Intraocular pressure, Metalorganic frameworks (MOFs), Ocular lens, Porous metal, Sustained release, Controlled drug delivery",
author = "A.V. Yaremenko and R.O. Melikov and N.A. Pechnikova and I.B. Belyaev and A. Ringaci and T.V. Yaremenko and A.B. Mirkasymov and A.A. Tamgin and V.I. Rodionov and S.M. Dolotova and G.A. Plisko and E.D. Semivelichenko and A.S. Rogova and A.R. Muslimov and A.S. Ivkina and D.Y. Ivkin and V.P. Erichev and S.M. Deyev and S.E. Avetisov and Y. Li and H.-J. Liu and I.V. Zelepukin",
note = "Export Date: 01 November 2025; Cited By: 3; Correspondence Address: A.V. Yaremenko; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States; email: dr.alex.yar@gmail.com; H.-J. Liu; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States; email: hliu40@bwh.harvard.edu; I.V. Zelepukin; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation; email: ivan.zelepukin@ilk.uu.se",
year = "2024",
doi = "10.1002/agt2.586",
language = "Английский",
volume = "5",
journal = "Aggregate",
issn = "2766-8541",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Modification of contact lenses via metal-organic frameworks for glaucoma treatment

AU - Yaremenko, A.V.

AU - Melikov, R.O.

AU - Pechnikova, N.A.

AU - Belyaev, I.B.

AU - Ringaci, A.

AU - Yaremenko, T.V.

AU - Mirkasymov, A.B.

AU - Tamgin, A.A.

AU - Rodionov, V.I.

AU - Dolotova, S.M.

AU - Plisko, G.A.

AU - Semivelichenko, E.D.

AU - Rogova, A.S.

AU - Muslimov, A.R.

AU - Ivkina, A.S.

AU - Ivkin, D.Y.

AU - Erichev, V.P.

AU - Deyev, S.M.

AU - Avetisov, S.E.

AU - Li, Y.

AU - Liu, H.-J.

AU - Zelepukin, I.V.

N1 - Export Date: 01 November 2025; Cited By: 3; Correspondence Address: A.V. Yaremenko; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States; email: dr.alex.yar@gmail.com; H.-J. Liu; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States; email: hliu40@bwh.harvard.edu; I.V. Zelepukin; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation; email: ivan.zelepukin@ilk.uu.se

PY - 2024

Y1 - 2024

N2 - The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure. Here, human contact lenses are modified with highly porous metal-organic frameworks with sustained release of brimonidine for prolonged glaucoma treatment. Various metal-organic frameworks were screened for their attachment to lenses, loading with brimonidine, and drug-release properties. Optimized therapeutic ocular lenses conjugated with MIL-101(Cr) frameworks maintain optical transparency and power. Coating of lenses with MIL-101(Cr) nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the cornea. The hybrid lenses provided a 4.5-fold better decrease in eye pressure, compared by area under the curve (AUC) value to a commercially available brimonidine tartrate solution. Therapeutic lenses did not induce any notable eye irritation or corneal damage in vivo. The newly developed hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases. © 2024 Elsevier B.V., All rights reserved.

AB - The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure. Here, human contact lenses are modified with highly porous metal-organic frameworks with sustained release of brimonidine for prolonged glaucoma treatment. Various metal-organic frameworks were screened for their attachment to lenses, loading with brimonidine, and drug-release properties. Optimized therapeutic ocular lenses conjugated with MIL-101(Cr) frameworks maintain optical transparency and power. Coating of lenses with MIL-101(Cr) nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the cornea. The hybrid lenses provided a 4.5-fold better decrease in eye pressure, compared by area under the curve (AUC) value to a commercially available brimonidine tartrate solution. Therapeutic lenses did not induce any notable eye irritation or corneal damage in vivo. The newly developed hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases. © 2024 Elsevier B.V., All rights reserved.

KW - brimonidine

KW - contact lenses

KW - drug delivery

KW - glaucoma

KW - intraocular pressure

KW - metal-organic frameworks

KW - nanoparticles

KW - Contact lenses

KW - Disease control

KW - Metal nanoparticles

KW - Metal-Organic Frameworks

KW - Ophthalmology

KW - Targeted drug delivery

KW - Australia

KW - Brimonidine

KW - Drug release properties

KW - Glaucoma

KW - Hybrid lens

KW - Intraocular pressure

KW - Metalorganic frameworks (MOFs)

KW - Ocular lens

KW - Porous metal

KW - Sustained release

KW - Controlled drug delivery

U2 - 10.1002/agt2.586

DO - 10.1002/agt2.586

M3 - статья

VL - 5

JO - Aggregate

JF - Aggregate

SN - 2766-8541

IS - 5

ER -

ID: 143420750