Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Modeling Tauopathies in Zebrafish (Danio rerio). / Калуев, Алан Валерьевич; Колесникова, Татьяна Олеговна; Котова, Мария Михайловна.
в: Journal of Evolutionary Biochemistry and Physiology, Том 59, № 6, 09.01.2024, стр. 2055-2071.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Modeling Tauopathies in Zebrafish (Danio rerio)
AU - Калуев, Алан Валерьевич
AU - Колесникова, Татьяна Олеговна
AU - Котова, Мария Михайловна
N1 - Kotova, М.М., Kolesnikova, Т.О. & Kalueff, A.V. Modeling Tauopathies in Zebrafish (Danio rerio). J Evol Biochem Phys 59, 2055–2071 (2023). https://doi.org/10.1134/S0022093023060133
PY - 2024/1/9
Y1 - 2024/1/9
N2 - Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of the tau protein in the brain, which causes clinical dementia. The tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, it aggregates in the brain. Tauopaties can be divided into primary and secondary (e.g., Alzheimer’s disease). Experimental animal models are an important tool to study tauopathies. Here, we discuss molecular mechanisms of tauopathies and their available experimental models in both rodents and a relatively novel model organism, the zebrafish (Danio rerio), as well as outline novel research trends in this field.
AB - Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of the tau protein in the brain, which causes clinical dementia. The tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, it aggregates in the brain. Tauopaties can be divided into primary and secondary (e.g., Alzheimer’s disease). Experimental animal models are an important tool to study tauopathies. Here, we discuss molecular mechanisms of tauopathies and their available experimental models in both rodents and a relatively novel model organism, the zebrafish (Danio rerio), as well as outline novel research trends in this field.
UR - https://www.mendeley.com/catalogue/d71f5536-19c9-3212-9b52-38e3da8fca17/
U2 - 10.1134/s0022093023060133
DO - 10.1134/s0022093023060133
M3 - Article
VL - 59
SP - 2055
EP - 2071
JO - Journal of Evolutionary Biochemistry and Physiology
JF - Journal of Evolutionary Biochemistry and Physiology
SN - 0022-0930
IS - 6
ER -
ID: 113569615