The violation of spatial parity symmetry ($$P$$) in strong interactions have never been observed experimentally. However a $$P$$-breaking term can be included in the QCD Lagrangian. Hence, the local parity symmetry breaking can occur due to large topological fluctuations at high temperature with dynamic generation of nontrivial topological charge configurations. A necessary condition for observing these effects is a sufficiently large space dimension and a long lifetime of a hot drop of QCD medium, which is available in central nuclear collisions at the LHC. In order to study the effects caused by local $$P$$-breaking in relativistic heavy-ion collisions we integrated them in Monte Carlo generators. Based on the analysis of the Monte Carlo data on the studied observables, taking into account the responses of the detecting systems of the ALICE facility under LHC Run 2 and Run 3 conditions, recommendations will be given on the criteria for selecting events, tracks, and choosing kinematic variables in terms of increasing sensitivity to the effects of local parity non-conservation.