Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Model system for multifunctional delivery nanoplatforms based on DNA-Polymer complexes containing silver nanoparticles and fluorescent dye. / Kasyanenko, Nina; Bakulev, Vladimir; Perevyazko, Igor; Nekrasova, Tatiana; Nazarova, Olga; Slita, Alexandr; Zolotova, Yulia; Panarin, Euginii.
в: Journal of Biotechnology, Том 236, № Supplement C, 2016, стр. 78-87.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Model system for multifunctional delivery nanoplatforms based on DNA-Polymer complexes containing silver nanoparticles and fluorescent dye
AU - Kasyanenko, Nina
AU - Bakulev, Vladimir
AU - Perevyazko, Igor
AU - Nekrasova, Tatiana
AU - Nazarova, Olga
AU - Slita, Alexandr
AU - Zolotova, Yulia
AU - Panarin, Euginii
PY - 2016
Y1 - 2016
N2 - Creation of multifunctional nanoplatforms is one of the new approaches to complex treatment and diagnosis with the monitoring of the curative process. Inclusion of various components into the drug delivery system may reduce toxicity and enhance or modify the therapeutic effects of medicines. In particular, some properties of metal nanoparticles and nanoclusters provide the ability to create new systems for treatment and diagnosis of diseases, biocatalysis and imaging of objects. For example, the ability of metal nanoparticles to enhance the quantum yield of luminescence can be used in bioimaging and therapy.The aim of the research was to construct and examine a multicomponent system based on DNA-polycation compact structure with the inclusion of silver nanoparticles and luminescent dye as a model system for delivery of genes and drugs with the possibility of modification and enhancement of their action. (C) 2016 Elsevier B.V. All rights reserved.
AB - Creation of multifunctional nanoplatforms is one of the new approaches to complex treatment and diagnosis with the monitoring of the curative process. Inclusion of various components into the drug delivery system may reduce toxicity and enhance or modify the therapeutic effects of medicines. In particular, some properties of metal nanoparticles and nanoclusters provide the ability to create new systems for treatment and diagnosis of diseases, biocatalysis and imaging of objects. For example, the ability of metal nanoparticles to enhance the quantum yield of luminescence can be used in bioimaging and therapy.The aim of the research was to construct and examine a multicomponent system based on DNA-polycation compact structure with the inclusion of silver nanoparticles and luminescent dye as a model system for delivery of genes and drugs with the possibility of modification and enhancement of their action. (C) 2016 Elsevier B.V. All rights reserved.
KW - DNA-PDMAEM complexes
KW - Silver nanoparticles
KW - Gene vectors with silver nanoparticles and fluorescent dye
KW - GENE DELIVERY
KW - SURFACE-CHARGE
KW - BINDING MODES
KW - PARTICLE-SIZE
KW - DAPI
KW - TOXICITY
KW - THERAPY
KW - CELLS
KW - SIRNA
KW - DRUG
U2 - 10.1016/j.jbiotec.2016.08.010
DO - 10.1016/j.jbiotec.2016.08.010
M3 - статья
VL - 236
SP - 78
EP - 87
JO - Journal of Biotechnology
JF - Journal of Biotechnology
SN - 0168-1656
IS - Supplement C
ER -
ID: 7598652