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Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery. / Lomivorotov, Vladimir V.; Efremov, Sergey M.; Kalinichenko, Andrey P.; Kornilov, Igor A.; Knazkova, Lubov G.; Chernyavskiy, Alexandr M.; Lomivorotov, Vladimir N.; Karaskov, Alexander M.

в: Heart Lung and Circulation, Том 22, № 1, 01.01.2013, стр. 25-30.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Lomivorotov, VV, Efremov, SM, Kalinichenko, AP, Kornilov, IA, Knazkova, LG, Chernyavskiy, AM, Lomivorotov, VN & Karaskov, AM 2013, 'Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery', Heart Lung and Circulation, Том. 22, № 1, стр. 25-30. https://doi.org/10.1016/j.hlc.2012.08.001

APA

Lomivorotov, V. V., Efremov, S. M., Kalinichenko, A. P., Kornilov, I. A., Knazkova, L. G., Chernyavskiy, A. M., Lomivorotov, V. N., & Karaskov, A. M. (2013). Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery. Heart Lung and Circulation, 22(1), 25-30. https://doi.org/10.1016/j.hlc.2012.08.001

Vancouver

Lomivorotov VV, Efremov SM, Kalinichenko AP, Kornilov IA, Knazkova LG, Chernyavskiy AM и пр. Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery. Heart Lung and Circulation. 2013 Янв. 1;22(1):25-30. https://doi.org/10.1016/j.hlc.2012.08.001

Author

Lomivorotov, Vladimir V. ; Efremov, Sergey M. ; Kalinichenko, Andrey P. ; Kornilov, Igor A. ; Knazkova, Lubov G. ; Chernyavskiy, Alexandr M. ; Lomivorotov, Vladimir N. ; Karaskov, Alexander M. / Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery. в: Heart Lung and Circulation. 2013 ; Том 22, № 1. стр. 25-30.

BibTeX

@article{95c6a6ee9bf3418cb62f5122b2b95022,
title = "Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery",
abstract = "Background: The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass. Methods: In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO2/FiO2 coefficient, and microalbuminuria. Results: Endothelin-1 was higher in the study group postoperatively at 10min (p=0.0008), 2h (p=0.02), 4h (p=0.005), and 24h (p=0.004). IL-6 was lower in the study group postoperatively at 2h (p=0.03), 4h (p=0.04), and 24h (p<0.0001). IL-10 was higher in the study group postoperatively at 10min (p<0.0001), 2h (p=0.009), and 4h (p=0.001). PaO2/FiO2 was lower in the study group at 24h after surgery (p=0.03). Microalbuminuria was similar in both groups. Conclusion: Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass.",
keywords = "Cardiopulmonary bypass, E-selectin, Endothelial cell, Endothelin-1, Methylprednisolone",
author = "Lomivorotov, {Vladimir V.} and Efremov, {Sergey M.} and Kalinichenko, {Andrey P.} and Kornilov, {Igor A.} and Knazkova, {Lubov G.} and Chernyavskiy, {Alexandr M.} and Lomivorotov, {Vladimir N.} and Karaskov, {Alexander M.}",
year = "2013",
month = jan,
day = "1",
doi = "10.1016/j.hlc.2012.08.001",
language = "English",
volume = "22",
pages = "25--30",
journal = "Heart Lung and Circulation",
issn = "1443-9506",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery

AU - Lomivorotov, Vladimir V.

AU - Efremov, Sergey M.

AU - Kalinichenko, Andrey P.

AU - Kornilov, Igor A.

AU - Knazkova, Lubov G.

AU - Chernyavskiy, Alexandr M.

AU - Lomivorotov, Vladimir N.

AU - Karaskov, Alexander M.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass. Methods: In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO2/FiO2 coefficient, and microalbuminuria. Results: Endothelin-1 was higher in the study group postoperatively at 10min (p=0.0008), 2h (p=0.02), 4h (p=0.005), and 24h (p=0.004). IL-6 was lower in the study group postoperatively at 2h (p=0.03), 4h (p=0.04), and 24h (p<0.0001). IL-10 was higher in the study group postoperatively at 10min (p<0.0001), 2h (p=0.009), and 4h (p=0.001). PaO2/FiO2 was lower in the study group at 24h after surgery (p=0.03). Microalbuminuria was similar in both groups. Conclusion: Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass.

AB - Background: The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass. Methods: In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO2/FiO2 coefficient, and microalbuminuria. Results: Endothelin-1 was higher in the study group postoperatively at 10min (p=0.0008), 2h (p=0.02), 4h (p=0.005), and 24h (p=0.004). IL-6 was lower in the study group postoperatively at 2h (p=0.03), 4h (p=0.04), and 24h (p<0.0001). IL-10 was higher in the study group postoperatively at 10min (p<0.0001), 2h (p=0.009), and 4h (p=0.001). PaO2/FiO2 was lower in the study group at 24h after surgery (p=0.03). Microalbuminuria was similar in both groups. Conclusion: Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass.

KW - Cardiopulmonary bypass

KW - E-selectin

KW - Endothelial cell

KW - Endothelin-1

KW - Methylprednisolone

UR - http://www.scopus.com/inward/record.url?scp=84872414846&partnerID=8YFLogxK

U2 - 10.1016/j.hlc.2012.08.001

DO - 10.1016/j.hlc.2012.08.001

M3 - Article

C2 - 22939108

AN - SCOPUS:84872414846

VL - 22

SP - 25

EP - 30

JO - Heart Lung and Circulation

JF - Heart Lung and Circulation

SN - 1443-9506

IS - 1

ER -

ID: 43525033