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Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery. / Lomivorotov, Vladimir V.; Efremov, Sergey M.; Kalinichenko, Andrey P.; Kornilov, Igor A.; Knazkova, Lubov G.; Chernyavskiy, Alexandr M.; Lomivorotov, Vladimir N.; Karaskov, Alexander M.
в: Heart Lung and Circulation, Том 22, № 1, 01.01.2013, стр. 25-30.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery
AU - Lomivorotov, Vladimir V.
AU - Efremov, Sergey M.
AU - Kalinichenko, Andrey P.
AU - Kornilov, Igor A.
AU - Knazkova, Lubov G.
AU - Chernyavskiy, Alexandr M.
AU - Lomivorotov, Vladimir N.
AU - Karaskov, Alexander M.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Background: The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass. Methods: In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO2/FiO2 coefficient, and microalbuminuria. Results: Endothelin-1 was higher in the study group postoperatively at 10min (p=0.0008), 2h (p=0.02), 4h (p=0.005), and 24h (p=0.004). IL-6 was lower in the study group postoperatively at 2h (p=0.03), 4h (p=0.04), and 24h (p<0.0001). IL-10 was higher in the study group postoperatively at 10min (p<0.0001), 2h (p=0.009), and 4h (p=0.001). PaO2/FiO2 was lower in the study group at 24h after surgery (p=0.03). Microalbuminuria was similar in both groups. Conclusion: Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass.
AB - Background: The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass. Methods: In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO2/FiO2 coefficient, and microalbuminuria. Results: Endothelin-1 was higher in the study group postoperatively at 10min (p=0.0008), 2h (p=0.02), 4h (p=0.005), and 24h (p=0.004). IL-6 was lower in the study group postoperatively at 2h (p=0.03), 4h (p=0.04), and 24h (p<0.0001). IL-10 was higher in the study group postoperatively at 10min (p<0.0001), 2h (p=0.009), and 4h (p=0.001). PaO2/FiO2 was lower in the study group at 24h after surgery (p=0.03). Microalbuminuria was similar in both groups. Conclusion: Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass.
KW - Cardiopulmonary bypass
KW - E-selectin
KW - Endothelial cell
KW - Endothelin-1
KW - Methylprednisolone
UR - http://www.scopus.com/inward/record.url?scp=84872414846&partnerID=8YFLogxK
U2 - 10.1016/j.hlc.2012.08.001
DO - 10.1016/j.hlc.2012.08.001
M3 - Article
C2 - 22939108
AN - SCOPUS:84872414846
VL - 22
SP - 25
EP - 30
JO - Heart Lung and Circulation
JF - Heart Lung and Circulation
SN - 1443-9506
IS - 1
ER -
ID: 43525033