TY - JOUR

T1 - Methyl-β-cyclodextrin inhibits Ca2+-responses induced by glutoxim and molixan in macrophages

AU - Krutetskaya, Z.I.

AU - Milenina, L.S.

AU - Naumova, A.A.

AU - Butov, S.N.

AU - Antonov, V.G.

AU - Nozdrachev, A.D.

N1 - Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Methyl-β-cyclodextrin inhibits Ca2+-responses induced by glutoxim and molixan in macrophages. Dokl Biochem Biophys 471, 390–392 (2016). https://doi.org/10.1134/S1607672916060041

PY - 2016

Y1 - 2016

N2 - Using Fura-2AM microfluorimetry, we have shown for the first time that methyl-β-cyclodextrin, inducing cholesterol extraction from membranes and raft disruption, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest that intact rafts are necessary for signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

AB - Using Fura-2AM microfluorimetry, we have shown for the first time that methyl-β-cyclodextrin, inducing cholesterol extraction from membranes and raft disruption, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest that intact rafts are necessary for signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

U2 - 10.1134/S1607672916060041

DO - 10.1134/S1607672916060041

M3 - Article

VL - 471

SP - 390

EP - 392

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -