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Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure. / Okrugin, Boris; Ilyash, Maxim; Markelov, Denis; Neelov, Igor.

в: Pharmaceutics, Том 10, № 3, 129, 09.2018.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Okrugin, B, Ilyash, M, Markelov, D & Neelov, I 2018, 'Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure', Pharmaceutics, Том. 10, № 3, 129. https://doi.org/10.3390/pharmaceutics10030129

APA

Okrugin, B., Ilyash, M., Markelov, D., & Neelov, I. (2018). Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure. Pharmaceutics, 10(3), [129]. https://doi.org/10.3390/pharmaceutics10030129

Vancouver

Okrugin B, Ilyash M, Markelov D, Neelov I. Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure. Pharmaceutics. 2018 Сент.;10(3). 129. https://doi.org/10.3390/pharmaceutics10030129

Author

Okrugin, Boris ; Ilyash, Maxim ; Markelov, Denis ; Neelov, Igor. / Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure. в: Pharmaceutics. 2018 ; Том 10, № 3.

BibTeX

@article{75d015449c6d43639692b5c0f83f6962,
title = "Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure",
abstract = "Poly-l-ysine dendrigrafts are promising systems for biomedical applications due to their biodegradability, biocompatibility, and similarity to dendrimers. There are many papers about the use of dendrigrafts as nanocontainers for drug delivery. At the same time, the number of studies about their physical properties is limited, and computer simulations of dendrigrafts are almost absent. This paper presents the results of a systematic molecular dynamics simulation study of third-generation lysine dendrigrafts with different topologies. The size and internal structures of the dendrigrafts were calculated. We discovered that the size of dendrigrafts of the same molecular weight depends on their topology. The shape of all studied dendrigrafts is close to spherical. Density profile of dendrigrafts depends on their topology.",
keywords = "Dendrigrafts, Molecular dynamics simulation, Poly-L-lysine, LATTICE NMR RELAXATION, MANIFESTATION, molecular dynamics simulation, dendrigrafts, MOLECULAR-DYNAMICS SIMULATION, POLYELECTROLYTE, BROWNIAN DYNAMICS, CONFORMATIONS, PEPTIDE DENDRIMERS, poly-L-lysine, POLY-L-LYSINE, CARBOSILANE DENDRIMER, ELONGATIONAL FLOW",
author = "Boris Okrugin and Maxim Ilyash and Denis Markelov and Igor Neelov",
year = "2018",
month = sep,
doi = "10.3390/pharmaceutics10030129",
language = "English",
volume = "10",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "3",

}

RIS

TY - JOUR

T1 - Lysine Dendrigraft Nanocontainers. Influence of Topology on Their Size and Internal Structure

AU - Okrugin, Boris

AU - Ilyash, Maxim

AU - Markelov, Denis

AU - Neelov, Igor

PY - 2018/9

Y1 - 2018/9

N2 - Poly-l-ysine dendrigrafts are promising systems for biomedical applications due to their biodegradability, biocompatibility, and similarity to dendrimers. There are many papers about the use of dendrigrafts as nanocontainers for drug delivery. At the same time, the number of studies about their physical properties is limited, and computer simulations of dendrigrafts are almost absent. This paper presents the results of a systematic molecular dynamics simulation study of third-generation lysine dendrigrafts with different topologies. The size and internal structures of the dendrigrafts were calculated. We discovered that the size of dendrigrafts of the same molecular weight depends on their topology. The shape of all studied dendrigrafts is close to spherical. Density profile of dendrigrafts depends on their topology.

AB - Poly-l-ysine dendrigrafts are promising systems for biomedical applications due to their biodegradability, biocompatibility, and similarity to dendrimers. There are many papers about the use of dendrigrafts as nanocontainers for drug delivery. At the same time, the number of studies about their physical properties is limited, and computer simulations of dendrigrafts are almost absent. This paper presents the results of a systematic molecular dynamics simulation study of third-generation lysine dendrigrafts with different topologies. The size and internal structures of the dendrigrafts were calculated. We discovered that the size of dendrigrafts of the same molecular weight depends on their topology. The shape of all studied dendrigrafts is close to spherical. Density profile of dendrigrafts depends on their topology.

KW - Dendrigrafts

KW - Molecular dynamics simulation

KW - Poly-L-lysine

KW - LATTICE NMR RELAXATION

KW - MANIFESTATION

KW - molecular dynamics simulation

KW - dendrigrafts

KW - MOLECULAR-DYNAMICS SIMULATION

KW - POLYELECTROLYTE

KW - BROWNIAN DYNAMICS

KW - CONFORMATIONS

KW - PEPTIDE DENDRIMERS

KW - poly-L-lysine

KW - POLY-L-LYSINE

KW - CARBOSILANE DENDRIMER

KW - ELONGATIONAL FLOW

UR - http://www.scopus.com/inward/record.url?scp=85052111603&partnerID=8YFLogxK

U2 - 10.3390/pharmaceutics10030129

DO - 10.3390/pharmaceutics10030129

M3 - Article

C2 - 30104488

VL - 10

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 3

M1 - 129

ER -

ID: 30564547