TY - JOUR

T1 - Local relapse of the prostate cancer following radical prostatectomy. Transrectal ultrasound diagnosis

AU - Minko, B. A.

AU - Karelin, M. I.

AU - Evtushenko, E. V.

AU - Shkolnik, M. I.

AU - Prohorov, D. G.

N1 - Publisher Copyright: © 2008 ABC-press Publishing House. All rights reserved.

PY - 2008

Y1 - 2008

N2 - Research purpose. Investigate possibilities of the transrectal ultrasonography (TRUS) in early diagnostics of the local recurrence of the prostate cancer (PC) following radical prostatectomy (RPE). Materials and methods. 50 PC patients at the age of 52 73 years (mean age 62,5 years) that have undergone RPE in different clinics were under our observation. Preoperational prostate-specific antigen (PSA) value mounted 1,7 30 ng/ml. The following stages were determined clinically: T1N0M0 8 patients, T2N0M0 42 patients (T2a 38, T2b 2, T2c 2). Following RPE, a positive surgical edge was revealed in 7 patients, tumor invasion to the seminal vesicles in 3. After performed RPE, PSA level was determined 1 time per 3 months and TRUS in B-mode using energetic mapping (EM) was performed in all the patients. For this, MEDISON company SonoAce 8800 device with convex intracavitary sensor with a frequency 7,5 MHz was used. Results. In 1,5 years after RPE, PSA level increase more then 0,2 ng/ml (0,58 28 ng/ml) was observed. Patients have been examined, including: digital rectal investigation (DRI), TRUS of the prostate bed, helical computed tomography (HCT) of the minor pelvis organs, skeleton scintigraphy. DRI revealed a hardening part in 1 patient, bone metastatic lesion in 2 patients. Via HCT of the minor pelvis organs, a pathologic structure in the prostate bed region with invasion of the posterior bladder wall was revealed. By B-mode TRUS using EM, the areas of solid structure in the region of vesico-urethral anastomosis or behind the posterior bladder wall were revealed in 9 patients, including hypoechogenic with deformed coiled vessels in 6, isoechogenic with solitary signals by EM in 2, mixed echogenicity with the posterior bladder wall invasion in 1 patients. By histological examination of the biopsy materials from the doubtful regions, the PC recurrence is diagnosed in 8 patients, in 1 histologically local PC recurrence has not been confirmed. Conclusions. TRUS with using EM is a higly informative, economically and clinically significant method of early diagnostics of the local PC recurrence following RPE.

AB - Research purpose. Investigate possibilities of the transrectal ultrasonography (TRUS) in early diagnostics of the local recurrence of the prostate cancer (PC) following radical prostatectomy (RPE). Materials and methods. 50 PC patients at the age of 52 73 years (mean age 62,5 years) that have undergone RPE in different clinics were under our observation. Preoperational prostate-specific antigen (PSA) value mounted 1,7 30 ng/ml. The following stages were determined clinically: T1N0M0 8 patients, T2N0M0 42 patients (T2a 38, T2b 2, T2c 2). Following RPE, a positive surgical edge was revealed in 7 patients, tumor invasion to the seminal vesicles in 3. After performed RPE, PSA level was determined 1 time per 3 months and TRUS in B-mode using energetic mapping (EM) was performed in all the patients. For this, MEDISON company SonoAce 8800 device with convex intracavitary sensor with a frequency 7,5 MHz was used. Results. In 1,5 years after RPE, PSA level increase more then 0,2 ng/ml (0,58 28 ng/ml) was observed. Patients have been examined, including: digital rectal investigation (DRI), TRUS of the prostate bed, helical computed tomography (HCT) of the minor pelvis organs, skeleton scintigraphy. DRI revealed a hardening part in 1 patient, bone metastatic lesion in 2 patients. Via HCT of the minor pelvis organs, a pathologic structure in the prostate bed region with invasion of the posterior bladder wall was revealed. By B-mode TRUS using EM, the areas of solid structure in the region of vesico-urethral anastomosis or behind the posterior bladder wall were revealed in 9 patients, including hypoechogenic with deformed coiled vessels in 6, isoechogenic with solitary signals by EM in 2, mixed echogenicity with the posterior bladder wall invasion in 1 patients. By histological examination of the biopsy materials from the doubtful regions, the PC recurrence is diagnosed in 8 patients, in 1 histologically local PC recurrence has not been confirmed. Conclusions. TRUS with using EM is a higly informative, economically and clinically significant method of early diagnostics of the local PC recurrence following RPE.

UR - http://www.scopus.com/inward/record.url?scp=85107039019&partnerID=8YFLogxK

U2 - 10.17650/1726-9776-2008-4-2-53-56

DO - 10.17650/1726-9776-2008-4-2-53-56

M3 - Article

AN - SCOPUS:85107039019

VL - 4

SP - 53

EP - 56

JO - Onkourologiya

JF - Onkourologiya

SN - 1726-9776

IS - 2

ER -