Результаты исследований: Научные публикации в периодических изданиях › статья
Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites. / Тихонов, Денис Борисович; Магазаник, Лев Гиршевич; Nagaeva, E.I.
в: Acta Naturae (англоязычная версия), Том 11, № 1 (40), 2019, стр. 4-13.Результаты исследований: Научные публикации в периодических изданиях › статья
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TY - JOUR
T1 - Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites.
AU - Тихонов, Денис Борисович
AU - Магазаник, Лев Гиршевич
AU - Nagaeva, E.I.
PY - 2019
Y1 - 2019
N2 - The proton-gated cationic channels belonging to the ASIC family are widely distributed in the central nervous system of vertebrates and play an important role in several physiological and pathological processes. ASIC1a are most sensitive to acidification of the external medium, which is the reason for the current interest in their function and pharmacology. Recently, the list of ASIC1a ligands has been rapidly expanding. It includes inorganic cations, a large number of synthetic and endogenous small molecules, and peptide toxins. The information on the mechanisms of action and the binding sites of the ligands comes from electrophysiological, mutational and structural studies. In the present review, we attempt to present a systematic view of the complex pattern of interactions between ligands and ASIC1a.
AB - The proton-gated cationic channels belonging to the ASIC family are widely distributed in the central nervous system of vertebrates and play an important role in several physiological and pathological processes. ASIC1a are most sensitive to acidification of the external medium, which is the reason for the current interest in their function and pharmacology. Recently, the list of ASIC1a ligands has been rapidly expanding. It includes inorganic cations, a large number of synthetic and endogenous small molecules, and peptide toxins. The information on the mechanisms of action and the binding sites of the ligands comes from electrophysiological, mutational and structural studies. In the present review, we attempt to present a systematic view of the complex pattern of interactions between ligands and ASIC1a.
KW - ASIC
KW - binding sites
KW - cns
KW - inhibition
KW - mechanisms of ligand-receptor interactions
KW - potentiation
KW - ASIC
KW - binding sites
KW - cns
KW - inhibition
KW - mechanisms of ligand-receptor interactions
KW - potentiation
M3 - Article
VL - 11
SP - 4
EP - 13
JO - Acta Naturae
JF - Acta Naturae
SN - 2075-8251
IS - 1 (40)
ER -
ID: 78619501