TY - JOUR

T1 - Legal aspects of zebrafish neuropharmacology and neurotoxicology research

AU - de Abreu, Murilo S.

AU - Giacomini, Ana C.V.V.

AU - Echevarria, David J.

AU - Kalueff, Allan V.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Despite the growing emphasis on translational neuropharmacology and drug discovery research, the legality underlying these fields are seldom considered. The zebrafish (Danio rerio) is an increasingly utilized model organism in neuropharmacology and neurotoxicology. As the acceptance of zebrafish in biomedicine continues to grow, the legal aspects of their applications remain outpaced by this exponential growth. Therefore, there is a need to evaluate the legal aspects of zebrafish applications to CNS drug research. Here, we discuss a wide range of regulatory topics relevant to zebrafish research, such as the bioethics of experimentation (including studies of stress and pain), welfare protection laws, the recent advances in CNS drug discovery, and specific legal aspects of controlled substance research in this aquatic species. The conceptualization and understanding of the zebrafish welfare and its promise as a model in toxicology can also potentially shape environmental protection practices and inform policy making.

AB - Despite the growing emphasis on translational neuropharmacology and drug discovery research, the legality underlying these fields are seldom considered. The zebrafish (Danio rerio) is an increasingly utilized model organism in neuropharmacology and neurotoxicology. As the acceptance of zebrafish in biomedicine continues to grow, the legal aspects of their applications remain outpaced by this exponential growth. Therefore, there is a need to evaluate the legal aspects of zebrafish applications to CNS drug research. Here, we discuss a wide range of regulatory topics relevant to zebrafish research, such as the bioethics of experimentation (including studies of stress and pain), welfare protection laws, the recent advances in CNS drug discovery, and specific legal aspects of controlled substance research in this aquatic species. The conceptualization and understanding of the zebrafish welfare and its promise as a model in toxicology can also potentially shape environmental protection practices and inform policy making.

KW - 3Rs

KW - Animal welfare regulations

KW - Pharmacology

KW - Toxicology

KW - Neuropharmacology/ethics

KW - Animal Experimentation/ethics

KW - Central Nervous System Agents/toxicity

KW - Stress, Physiological

KW - Zebrafish

KW - Drug Discovery

KW - Animals

KW - Pain

KW - Controlled Substances

KW - Disease Models, Animal

UR - http://www.scopus.com/inward/record.url?scp=85056826909&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/legal-aspects-zebrafish-neuropharmacology-neurotoxicology-research

U2 - 10.1016/j.yrtph.2018.11.007

DO - 10.1016/j.yrtph.2018.11.007

M3 - Review article

C2 - 30453007

AN - SCOPUS:85056826909

VL - 101

SP - 65

EP - 70

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

ER -