Standard

Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes. / Sokolov, A.V.; Zakahrova, E.T.; Kostevich, V.A.; Samygina, V.R.; Vasilyev, V.B.

в: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, Том 27, № 5, 2014, стр. 815-828.

Результаты исследований: Научные публикации в периодических изданияхстатья

Harvard

Sokolov, AV, Zakahrova, ET, Kostevich, VA, Samygina, VR & Vasilyev, VB 2014, 'Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes', Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, Том. 27, № 5, стр. 815-828. https://doi.org/10.1007/s10534-014-9755-2

APA

Sokolov, A. V., Zakahrova, E. T., Kostevich, V. A., Samygina, V. R., & Vasilyev, V. B. (2014). Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 27(5), 815-828. https://doi.org/10.1007/s10534-014-9755-2

Vancouver

Sokolov AV, Zakahrova ET, Kostevich VA, Samygina VR, Vasilyev VB. Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2014;27(5):815-828. https://doi.org/10.1007/s10534-014-9755-2

Author

Sokolov, A.V. ; Zakahrova, E.T. ; Kostevich, V.A. ; Samygina, V.R. ; Vasilyev, V.B. / Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes. в: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2014 ; Том 27, № 5. стр. 815-828.

BibTeX

@article{124ed99e4fbd4f5084c96e829cc3c025,
title = "Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes",
abstract = "Copper-containing plasma protein ceruloplasmin (Cp) forms a complex with lactoferrin (Lf), an iron-binding protein, and with the heme-containing myeloperoxidase (Mpo). In case of inflammation Lf and Mpo are secreted from the granules of neutrophils. Among the plasma proteins Cp seems to be the preferential partner of Lf and Mpo. After an intraperitoneal injection of Lf to rodents the “Cp-Lf” complex has been shown to appear in their bloodstream. Cp prevents the interaction of Lf with protoplasts of Micrococcus luteus. Upon immunoprecipitation of Cp the blood plasma becomes depleted of Lf and in dose-dependent manner loses the capacity to inhibit the peroxidase activity of Mpo, but not the Mpo-catalyzed oxidation of thiocyanate in the (pseudo)halogenating cycle. Antimicrobial effect against E.coli displayed by a synergistic system that includes Lf and Mpo-H2O2-chloride, but not thiocyanate, as the substrate for Mpo is abrogated when Cp is added. Hence, Cp can be regarded as an anti-inflammatory factor that res",
keywords = "ceruloplsamin, lactoferrin, myeloperoxidase, protein-protein interactions, synergism of antimicrobial proteins, inflammation, thiocyanate, halogenative stress.",
author = "A.V. Sokolov and E.T. Zakahrova and V.A. Kostevich and V.R. Samygina and V.B. Vasilyev",
year = "2014",
doi = "10.1007/s10534-014-9755-2",
language = "English",
volume = "27",
pages = "815--828",
journal = "BioMetals",
issn = "0966-0844",
publisher = "Springer Nature",
number = "5",

}

RIS

TY - JOUR

T1 - Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes

AU - Sokolov, A.V.

AU - Zakahrova, E.T.

AU - Kostevich, V.A.

AU - Samygina, V.R.

AU - Vasilyev, V.B.

PY - 2014

Y1 - 2014

N2 - Copper-containing plasma protein ceruloplasmin (Cp) forms a complex with lactoferrin (Lf), an iron-binding protein, and with the heme-containing myeloperoxidase (Mpo). In case of inflammation Lf and Mpo are secreted from the granules of neutrophils. Among the plasma proteins Cp seems to be the preferential partner of Lf and Mpo. After an intraperitoneal injection of Lf to rodents the “Cp-Lf” complex has been shown to appear in their bloodstream. Cp prevents the interaction of Lf with protoplasts of Micrococcus luteus. Upon immunoprecipitation of Cp the blood plasma becomes depleted of Lf and in dose-dependent manner loses the capacity to inhibit the peroxidase activity of Mpo, but not the Mpo-catalyzed oxidation of thiocyanate in the (pseudo)halogenating cycle. Antimicrobial effect against E.coli displayed by a synergistic system that includes Lf and Mpo-H2O2-chloride, but not thiocyanate, as the substrate for Mpo is abrogated when Cp is added. Hence, Cp can be regarded as an anti-inflammatory factor that res

AB - Copper-containing plasma protein ceruloplasmin (Cp) forms a complex with lactoferrin (Lf), an iron-binding protein, and with the heme-containing myeloperoxidase (Mpo). In case of inflammation Lf and Mpo are secreted from the granules of neutrophils. Among the plasma proteins Cp seems to be the preferential partner of Lf and Mpo. After an intraperitoneal injection of Lf to rodents the “Cp-Lf” complex has been shown to appear in their bloodstream. Cp prevents the interaction of Lf with protoplasts of Micrococcus luteus. Upon immunoprecipitation of Cp the blood plasma becomes depleted of Lf and in dose-dependent manner loses the capacity to inhibit the peroxidase activity of Mpo, but not the Mpo-catalyzed oxidation of thiocyanate in the (pseudo)halogenating cycle. Antimicrobial effect against E.coli displayed by a synergistic system that includes Lf and Mpo-H2O2-chloride, but not thiocyanate, as the substrate for Mpo is abrogated when Cp is added. Hence, Cp can be regarded as an anti-inflammatory factor that res

KW - ceruloplsamin

KW - lactoferrin

KW - myeloperoxidase

KW - protein-protein interactions

KW - synergism of antimicrobial proteins

KW - inflammation

KW - thiocyanate

KW - halogenative stress.

U2 - 10.1007/s10534-014-9755-2

DO - 10.1007/s10534-014-9755-2

M3 - Article

VL - 27

SP - 815

EP - 828

JO - BioMetals

JF - BioMetals

SN - 0966-0844

IS - 5

ER -

ID: 7017870